四川理工学院学报：自然科学版
四川理工學院學報：自然科學版
사천리공학원학보：자연과학판
Journal of Sichuan University of Science & Engineering:Natural Science Editton
2012年
5期
6-10
,共5页
张智%李再新%赵志平%谢万如%刘章琴
張智%李再新%趙誌平%謝萬如%劉章琴
장지%리재신%조지평%사만여%류장금
嘌呤受体%胞外核苷酸%信号通路%免疫应答%炎症
嘌呤受體%胞外覈苷痠%信號通路%免疫應答%炎癥
표령수체%포외핵감산%신호통로%면역응답%염증
purinergic receptors%extracellular nucleotides%signaling pathway%immune response%inflammation
P2Y受体是嘌呤受体当中的一个小家族，属于GPCR8（G-proteincoupledreceptors）代谢型受体，通过选择性结合胞外核苷酸分子如ATP、ADP、UTP、UDP和UDP-glucose而激活。P2Y受体在全身各组织细胞中广泛表达，调控了细胞的多种生理功能。随着研究的深入，发现P2Y受体及其胞外核苷酸分子在免疫应答过程中亦发挥着重要的调控作用。
P2Y受體是嘌呤受體噹中的一箇小傢族，屬于GPCR8（G-proteincoupledreceptors）代謝型受體，通過選擇性結閤胞外覈苷痠分子如ATP、ADP、UTP、UDP和UDP-glucose而激活。P2Y受體在全身各組織細胞中廣汎錶達，調控瞭細胞的多種生理功能。隨著研究的深入，髮現P2Y受體及其胞外覈苷痠分子在免疫應答過程中亦髮揮著重要的調控作用。
P2Y수체시표령수체당중적일개소가족，속우GPCR8（G-proteincoupledreceptors）대사형수체，통과선택성결합포외핵감산분자여ATP、ADP、UTP、UDP화UDP-glucose이격활。P2Y수체재전신각조직세포중엄범표체，조공료세포적다충생리공능。수착연구적심입，발현P2Y수체급기포외핵감산분자재면역응답과정중역발휘착중요적조공작용。
P2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by extracellular nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. In recent years, evidences also has been shown that P2Y receptors play a key role in immune response, such as innate immunity and adaptive immunity.
