CAJ | 학술논문

以单甲氧基聚乙二醇-外消旋聚乳酸为载体制备包载厚朴酚的纳米胶束新剂型,观察胶束的形貌,测定胶束的平均粒径、载药量、药物包封率及进行体外释药实验.研究表明,所制备的厚朴酚胶束呈规则球状,胶束平均粒径达纳米级,胶束的体外释药具有缓释特性.
이단갑양기취을이순-외소선취유산위재체제비포재후박분적납미효속신제형,관찰효속적형모,측정효속적평균립경、재약량、약물포봉솔급진행체외석약실험.연구표명,소제비적후박분효속정규칙구상,효속평균립경체납미급,효속적체외석약구유완석특성.
The mPEG - PLA was applied as carder to encapsulate magnolol to form new dosage forms of nano - micelle. The shape of the nano - micelles were observed. The average size and the drug loading con - tent and encapsulation efficiency of the nano - micelles were determined. Solvent evaporation, the prepared magnolol micelles had nanosize and size distribution, they have excellent drug sustained- release behavior.