CAJ | 학술논문

研究血管内皮生长因子（VEGF）936^＊T／C基因多态性与胃癌之间的关系，了解该基因多态性对胃癌生成及发展的影响。采用聚合酶链反应一限制性片段长度多态性（PCR-RFLP）方法检测胃癌患者和健康者外周血的VEGF936。T／C基因型。结果，胃癌患者外周血中VEGF936。T／C基因型或等位基因与健康者相比无差异（精确概率法计算基因型P=0．226；卡方检验等位基因x^2=2．934，P=0．087）。Ⅲ、Ⅳ期病理分期患者C／C基因型和c等位基因比例（66．7％和82．0％）明显大于Ⅰ、Ⅱ期（12．9％和1．2％），两者差异有统计学意义（基因型：x^2：14．215，P=0．000；等位基因：X2=28．430，P=0．000）。结果表明，VEGF9360C／C基因多态性与胃癌的生成无关，而与胃癌的进展相关。
연구혈관내피생장인자（VEGF）936^＊T／C기인다태성여위암지간적관계，료해해기인다태성대위암생성급발전적영향。채용취합매련반응일한제성편단장도다태성（PCR-RFLP）방법검측위암환자화건강자외주혈적VEGF936。T／C기인형。결과，위암환자외주혈중VEGF936。T／C기인형혹등위기인여건강자상비무차이（정학개솔법계산기인형P=0．226；잡방검험등위기인x^2=2．934，P=0．087）。Ⅲ、Ⅳ기병리분기환자C／C기인형화c등위기인비례（66．7％화82．0％）명현대우Ⅰ、Ⅱ기（12．9％화1．2％），량자차이유통계학의의（기인형：x^2：14．215，P=0．000；등위기인：X2=28．430，P=0．000）。결과표명，VEGF9360C／C기인다태성여위암적생성무관，이여위암적진전상관。
Objective The study was to investigate the relationship between VEGF gene 936^*T/C polymorphism and gastric cancer. Methods VEGF936 ^*T/C genotypes was detected by PCR-RFLP in patients with gastric carcinoma and healthy controls. Results There was no significant difference in the gentype of VEGF936^*T/C or C allele between the patients and the control group ( genotype P=0.226; C allele x^2=2.934, P=0.087 ). The C/C genotype and C allele in patients at Ⅲ, Ⅳ staged ( 66.7% and 82.0% ) were more frequently found than in those with Ⅰ, Ⅱ staged (12.9% and 1.2%), so there was significant difference (C/C genotype; (x^2=14.215, P=0.000. C allele x^2-28.430, P=0.000 ). Conclusions VEGF936*C/C genotype is not related to the development of gastric carcinoma, but they both are related to the growth of the carcinoma.