中国实验方剂学杂志
中國實驗方劑學雜誌
중국실험방제학잡지
CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE
2013年
20期
24-26
,共3页
孔艳%李开%苏建春%赵俊霞%张立%尹蓉莉
孔豔%李開%囌建春%趙俊霞%張立%尹蓉莉
공염%리개%소건춘%조준하%장립%윤용리
满山红总黄酮%固体分散体%体外溶出%溶剂法%熔融法
滿山紅總黃酮%固體分散體%體外溶齣%溶劑法%鎔融法
만산홍총황동%고체분산체%체외용출%용제법%용융법
total flavonoids from Rhododendri Daurici Folium%solid dispersions%in vitro dissolution%solvent method%melting method
目的:优选满山红总黄酮固体分散体的制备工艺.方法:分别以聚乙二醇6000 (PEG6000),聚乙烯吡咯烷酮K30(PVPK30),泊洛沙姆188(Pluronic F68)为载体,采用适合载体的熔融-溶剂法和溶剂法制备满山红总黄酮-载体不同比例(1∶1,1∶2,1∶4,1∶6)的固体分散体.以满山红总黄酮为检测指标,通过UV测定体外溶出度,计算各固体分散体的Td值.结果:最佳制备工艺为以4倍量PVPK30为载体,加20倍量无水乙醇溶解,于50℃旋蒸除去无水乙醇,满山红总黄酮的体外溶出率达100％.PEG6000为载体时,不同比例的固体分散体Td分别为6.329,5.225,0.096,4.755 min;Pluronic F68为载体时,各固体分散体Td分别为4.045,3.561,0.018,0.026 min；PVPK30为载体时,各固体分散体Td分别为5.000,5.000,0.005,0.056 min.结论:溶剂法可用于制备满山红总黄酮固体分散体,具有很好的增溶效果,但不适合工业生产.
目的:優選滿山紅總黃酮固體分散體的製備工藝.方法:分彆以聚乙二醇6000 (PEG6000),聚乙烯吡咯烷酮K30(PVPK30),泊洛沙姆188(Pluronic F68)為載體,採用適閤載體的鎔融-溶劑法和溶劑法製備滿山紅總黃酮-載體不同比例(1∶1,1∶2,1∶4,1∶6)的固體分散體.以滿山紅總黃酮為檢測指標,通過UV測定體外溶齣度,計算各固體分散體的Td值.結果:最佳製備工藝為以4倍量PVPK30為載體,加20倍量無水乙醇溶解,于50℃鏇蒸除去無水乙醇,滿山紅總黃酮的體外溶齣率達100％.PEG6000為載體時,不同比例的固體分散體Td分彆為6.329,5.225,0.096,4.755 min;Pluronic F68為載體時,各固體分散體Td分彆為4.045,3.561,0.018,0.026 min；PVPK30為載體時,各固體分散體Td分彆為5.000,5.000,0.005,0.056 min.結論:溶劑法可用于製備滿山紅總黃酮固體分散體,具有很好的增溶效果,但不適閤工業生產.
목적:우선만산홍총황동고체분산체적제비공예.방법:분별이취을이순6000 (PEG6000),취을희필각완동K30(PVPK30),박락사모188(Pluronic F68)위재체,채용괄합재체적용융-용제법화용제법제비만산홍총황동-재체불동비례(1∶1,1∶2,1∶4,1∶6)적고체분산체.이만산홍총황동위검측지표,통과UV측정체외용출도,계산각고체분산체적Td치.결과:최가제비공예위이4배량PVPK30위재체,가20배량무수을순용해,우50℃선증제거무수을순,만산홍총황동적체외용출솔체100％.PEG6000위재체시,불동비례적고체분산체Td분별위6.329,5.225,0.096,4.755 min;Pluronic F68위재체시,각고체분산체Td분별위4.045,3.561,0.018,0.026 min；PVPK30위재체시,각고체분산체Td분별위5.000,5.000,0.005,0.056 min.결론:용제법가용우제비만산홍총황동고체분산체,구유흔호적증용효과,단불괄합공업생산.
