CAJ | 학술논문

目的探讨迷走神经干预对心房电重构的影响及意义.方法 30条杂种犬给予美托洛尔以消除交感神经对心房电重构的影响；观察使用阿托品前、后及心房电重构后高位右心房(SA)和冠状静脉窦(CS),迷走神经刺激(VS)下或无迷走神经刺激(Non-VS)下的心房有效不应期(ERP)及心房颤动易感窗口(VW).结果应用阿托品前,VS后发现ERP显著缩短[(54.83 ±46.23) ms],VW显著性增加[(19.86±13.23)ms],此时心房颤动易于发生；使用阿托品后,VS下的ERP明显延长[(112.33±9.63) ms],可并未诱发房颤；心房电经过重构后,基础和VS下的ERP与心房电重构前差异均无统计学意义(t=2.116、0.853,均P＞0.05).结论 VS可加重心房电重构,增加心房颤动易感性；迷走神经阻滞能减轻心房电重构,使心房颤动易感性降低.
목적 탐토미주신경간예대심방전중구적영향급의의.방법 30조잡충견급여미탁락이이소제교감신경대심방전중구적영향；관찰사용아탁품전、후급심방전중구후고위우심방(SA)화관상정맥두(CS),미주신경자격(VS)하혹무미주신경자격(Non-VS)하적심방유효불응기(ERP)급심방전동역감창구(VW).결과 응용아탁품전,VS후발현ERP현저축단[(54.83 ±46.23) ms],VW현저성증가[(19.86±13.23)ms],차시심방전동역우발생；사용아탁품후,VS하적ERP명현연장[(112.33±9.63) ms],가병미유발방전；심방전경과중구후,기출화VS하적ERP여심방전중구전차이균무통계학의의(t=2.116、0.853,균P＞0.05).결론 VS가가중심방전중구,증가심방전동역감성；미주신경조체능감경심방전중구,사심방전동역감성강저.
Objective To investigate the impact and significance of the vagus nerve intervention on the atrial electrical emodeling.Methods 30 mongrel dogs were given metoprolol in order to eliminate the effects of sympathetic nerve on atrial electrical remodeling;observe the atrial effective refractory period (ERP) and atrial fibrillation susceptible window(VW) in the high right atrial(SA) and coronary sinus (CS) by the vagus nerve stimulation(VS) or vagus nerve stimulation(Non-VS) before and after using atropine and after atrial electrical remodeling was observed.Results Before using vagus nerve blocking agents atropine,ERP shortened significantly [(54.83 ± 46.23) ms] and VW increased significantly [(19.86±13.23) ms] after VS,this time with atrial fibrillation-prone ; After using atropine,ERP increased significantly [(112.33 ± 9.63) ms] under VS,did not induce atrial fibrillation; After atrial electrical remodeling,the value of ERP was no significant difference under basis and VS (t =2.116,0.853,all P ＞0.05).Conclusion VS can increase the atrial electrical remodeling,an increase of atrial fibrillation susceptibility;vagus nerve block can reduce atrial electrical remodeling and atrial fibrillation susceptibility decreased.