中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2012年
12期
1071-1074
,共4页
张仁知%周纯武%李静%欧阳汉
張仁知%週純武%李靜%歐暘漢
장인지%주순무%리정%구양한
乳腺肿瘤%磁共振成像%对比分析
乳腺腫瘤%磁共振成像%對比分析
유선종류%자공진성상%대비분석
Breast neoplasms%Magnetic resonance imaging%Comparative study
目的 探讨MR DWI诊断非特殊型浸润性导管癌的价值,寻找较合适的诊断界值.方法 回顾性分析经手术病理证实的69例乳腺非特殊型浸润性导管癌(69个病灶)和67例良性肿块患者(69个病灶)资料,所有患者均行MR平扫和DWI检查,分别测量乳腺癌病灶和其对侧正常乳腺、良性病灶和其对侧正常乳腺组织的ADC值,并采用独立样本t检验进行比较,通过绘制各组ADC值的ROC曲线,寻找各组病变间ADC值的最佳诊断界值.结果 非特殊型浸润性乳腺癌肿瘤的ADC值为(0.925 ±0.268)×10-3 mm2/s,对侧正常乳腺组织ADC值为(1.680±0.446)×10-3mm2/s,差异有统计学意义(t=12.08,P＜0.01)；良性肿块的ADC值为(1.350±0.383)×10-3 mm2/s,对侧正常乳腺组织ADC值为(1.690±0.356)×10-3 mm2/s,差异有统计学意义(t=6.64,P＜0.01)；良、恶性病变的ADC值差异也有统计学意义(t=7.56,P＜0.01).将非特殊型浸润性乳腺癌肿瘤和其对侧正常乳腺组织、良性肿块和其对侧正常乳腺组织、恶性和良性肿瘤所得ADC值绘制ROC曲线,曲线下面积分别为0.915、0.794和0.847.ADC值鉴别恶性肿瘤与其对侧正常组织、良性肿瘤与其对侧正常组织、恶性肿瘤与良性肿瘤之间的最佳ADC值界值分别为1.185×10-3、1.505×10-3、1.015×10-3mm2/s,诊断的敏感度和特异度分别为89.9％和85.5％、79.7％和63.5％、75.4％和87.0％.结论 MR DWI对诊断非特殊型浸润性导管癌具有较好的价值,鉴别其与良性病变的ADC界值为1.015×10-3mm2/s.
目的 探討MR DWI診斷非特殊型浸潤性導管癌的價值,尋找較閤適的診斷界值.方法 迴顧性分析經手術病理證實的69例乳腺非特殊型浸潤性導管癌(69箇病竈)和67例良性腫塊患者(69箇病竈)資料,所有患者均行MR平掃和DWI檢查,分彆測量乳腺癌病竈和其對側正常乳腺、良性病竈和其對側正常乳腺組織的ADC值,併採用獨立樣本t檢驗進行比較,通過繪製各組ADC值的ROC麯線,尋找各組病變間ADC值的最佳診斷界值.結果 非特殊型浸潤性乳腺癌腫瘤的ADC值為(0.925 ±0.268)×10-3 mm2/s,對側正常乳腺組織ADC值為(1.680±0.446)×10-3mm2/s,差異有統計學意義(t=12.08,P＜0.01)；良性腫塊的ADC值為(1.350±0.383)×10-3 mm2/s,對側正常乳腺組織ADC值為(1.690±0.356)×10-3 mm2/s,差異有統計學意義(t=6.64,P＜0.01)；良、噁性病變的ADC值差異也有統計學意義(t=7.56,P＜0.01).將非特殊型浸潤性乳腺癌腫瘤和其對側正常乳腺組織、良性腫塊和其對側正常乳腺組織、噁性和良性腫瘤所得ADC值繪製ROC麯線,麯線下麵積分彆為0.915、0.794和0.847.ADC值鑒彆噁性腫瘤與其對側正常組織、良性腫瘤與其對側正常組織、噁性腫瘤與良性腫瘤之間的最佳ADC值界值分彆為1.185×10-3、1.505×10-3、1.015×10-3mm2/s,診斷的敏感度和特異度分彆為89.9％和85.5％、79.7％和63.5％、75.4％和87.0％.結論 MR DWI對診斷非特殊型浸潤性導管癌具有較好的價值,鑒彆其與良性病變的ADC界值為1.015×10-3mm2/s.
목적 탐토MR DWI진단비특수형침윤성도관암적개치,심조교합괄적진단계치.방법 회고성분석경수술병리증실적69례유선비특수형침윤성도관암(69개병조)화67례량성종괴환자(69개병조)자료,소유환자균행MR평소화DWI검사,분별측량유선암병조화기대측정상유선、량성병조화기대측정상유선조직적ADC치,병채용독립양본t검험진행비교,통과회제각조ADC치적ROC곡선,심조각조병변간ADC치적최가진단계치.결과 비특수형침윤성유선암종류적ADC치위(0.925 ±0.268)×10-3 mm2/s,대측정상유선조직ADC치위(1.680±0.446)×10-3mm2/s,차이유통계학의의(t=12.08,P＜0.01)；량성종괴적ADC치위(1.350±0.383)×10-3 mm2/s,대측정상유선조직ADC치위(1.690±0.356)×10-3 mm2/s,차이유통계학의의(t=6.64,P＜0.01)；량、악성병변적ADC치차이야유통계학의의(t=7.56,P＜0.01).장비특수형침윤성유선암종류화기대측정상유선조직、량성종괴화기대측정상유선조직、악성화량성종류소득ADC치회제ROC곡선,곡선하면적분별위0.915、0.794화0.847.ADC치감별악성종류여기대측정상조직、량성종류여기대측정상조직、악성종류여량성종류지간적최가ADC치계치분별위1.185×10-3、1.505×10-3、1.015×10-3mm2/s,진단적민감도화특이도분별위89.9％화85.5％、79.7％화63.5％、75.4％화87.0％.결론 MR DWI대진단비특수형침윤성도관암구유교호적개치,감별기여량성병변적ADC계치위1.015×10-3mm2/s.
Objective To explore the value of diffusion weighted imaging(DWI) in the diagnosis of "invasive ductal carcinoma not otherwise specified" and find a suitable diagnostic cutoff ADC value.Methods The MRI findings of 69 patients (69 lesions) of invasive ductal carcinoma not otherwise specified and 67 patients benign tumors (69 lesions) confirmed by pathology were evaluated.ADC values of the carcinoma,benign tumors and their contralateral normal breast tissues were obtained.Independent-samples t test and ROC curves were used.Results The ADC values of carcinoma and contralateral normal breast tissues were (0.925 ± 0.268) × 10-3 mm2/s and (1.680 ± 0.446) × 10-3 mm2/s respectively,their difference had statistical significance (t =12.08,P ＜ 0.01) ; The ADC values of benign tumor and contralateral normal breast tissues were (1.350 ± 0.383) × 10-3 mm2/s and (1.690± 0.356) × 10-3 mm2/s respectively,the difference had statistical significance (t =6.64,P ＜ 0.01); The difference between carcinoma and benign tumors had statistical significance as well (t =7.56,P ＜ 0.01).The area under the ROC curve of carcinoma and contralateral normal breast tissues,benign tumors and contralateral normal breast tissues,carcinoma and benign tumors were 0.915,0.794,0.847 respectively.The diagnostic cutoff value for each were 1.185 × 10-3 mm2/s,1.505 × 10-3 mm2/s,1.015 × 10-3 mm2/s respectively;Corresponding sensitivity and specificity were 89.9％ and 85.5％,79.7％ and 63.5％,75.4％ and 87.0％respectively.Conclusions MR-DWI is valuable in the diagnosis of invasive ductal carcinoma not otherwise specified.The best ADC diagnostic cutoff value to differentiate invasive ductal carcinoma not otherwise specified from benign tumors is 1.015 × 10-3mm2/s.
