CAJ | 학술논문

为提高复方甘草片的稳定性并改善其气味,优化了复方甘草片的薄膜包衣溶液组成.应用正交试验法,选择成膜材料、增塑剂和溶剂浓度作为考察因素,以外观变化、崩解时限、加速条件下片剂增重量作为指标,选用正交表L9（34）进行试验,筛选出薄膜包衣溶液的最佳质量百分数组成即羟丙甲纤维素5.36%,聚丙烯酸树酯1.84%,增塑剂0.12%,乙醇75%.结果表明：按最佳包衣液组成制备的复方甘草薄膜包衣片具有较好稳定性,且无明显特殊臭味.
위제고복방감초편적은정성병개선기기미,우화료복방감초편적박막포의용액조성.응용정교시험법,선택성막재료、증소제화용제농도작위고찰인소,이외관변화、붕해시한、가속조건하편제증중량작위지표,선용정교표L9（34）진행시험,사선출박막포의용액적최가질량백분수조성즉간병갑섬유소5.36%,취병희산수지1.84%,증소제0.12%,을순75%.결과표명：안최가포의액조성제비적복방감초박막포의편구유교호은정성,차무명현특수취미.
The formulation of film solution coating of compound liquorice tablets was optimized to improve their stability and smell.Through L9（34） orthogonal design,film polymers,plasticiser and solvent concentration were investigated to evaluate the effects on the exterior change,disintegration time and increased tablet weight under accelerated condition of the tablets.The optimized formulation of the film coating solution showed that the content of hydroxypropyl methylcellulose,polyacrylic resin,plasticiser and the concentration of ethanol were 5.36 %,1.84 %,0.12 % and 75 %,respectively.It was found that the stability and smell of compound liquorice tablets by the film coating solution were greatly improved.