CAJ | 학술논문

在严重脓毒症病程中,心血管功能障碍是普遍存在的.尽管常提到心脏功能性紊乱,但从血清中升高心肌蛋白水平以及病理检查发现心肌免疫细胞浸润、水肿和线粒体受损的证据来看,严重脓毒症时心脏结构可发生变化,从而导致心功能不全.应用血小板活化因子、环孢素、谷氨酰胺、咖啡因或辛伐他汀治疗可以预防心脏结构改变,改善心肌功能.本文就严重脓毒症时心脏结构病理改变的研究进展加以综述,以期加深对这些变化的认识.
재엄중농독증병정중,심혈관공능장애시보편존재적.진관상제도심장공능성문란,단종혈청중승고심기단백수평이급병리검사발현심기면역세포침윤、수종화선립체수손적증거래간,엄중농독증시심장결구가발생변화,종이도치심공능불전.응용혈소판활화인자、배포소、곡안선알、가배인혹신벌타정치료가이예방심장결구개변,개선심기공능.본문취엄중농독증시심장결구병리개변적연구진전가이종술,이기가심대저사변화적인식.
Cardiovascular dysfunction is common in severe sepsis.Although functional alteration is often described,the elevated serum levels of cardiac proteins and autopsy findings of myocardial immune cell infiltration,edema,and damaged mitochondria suggest that structural changes to the heart during severe sepsis may occur and may contribute to cardiac dysfunction.Myocardial functions may be improved by pretreatment with plateletactivating factor,cyclo-sporin A,glutamine,caffeine,simvastatin,or caspase inhibitors.We explored the advance on structural change of the heart during severe sepsis in order to deepen the understanding of these changes.