中华细胞与干细胞杂志(电子版)
中華細胞與榦細胞雜誌(電子版)
중화세포여간세포잡지(전자판)
CHINESE JOURNAL OF CELL AND STEM CELL
2014年
2期
104-108
,共5页
胚胎干细胞%色素上皮,眼%干细胞移植
胚胎榦細胞%色素上皮,眼%榦細胞移植
배태간세포%색소상피,안%간세포이식
Embryonic stem cell%Pigment epithelium of eye%Stem cell transplantation
Schwartz等报告的用从人胚胎干细胞分化成的视网膜色素上皮细胞(RPE)移植治疗视网膜病,已观察4月,尚属成功。这是首次用从人胚胎干细胞(hESC)定向分化而成的细胞移植至患者取得成功。本文复习RPE移植的历史与现况;hESC分化而成的RPE(hESC-RPE)的实验研究以及临床移植的意义、方法、效果及存在问题,并展望了应用干细胞分化的RPE移植的前景。
Schwartz等報告的用從人胚胎榦細胞分化成的視網膜色素上皮細胞(RPE)移植治療視網膜病,已觀察4月,尚屬成功。這是首次用從人胚胎榦細胞(hESC)定嚮分化而成的細胞移植至患者取得成功。本文複習RPE移植的歷史與現況;hESC分化而成的RPE(hESC-RPE)的實驗研究以及臨床移植的意義、方法、效果及存在問題,併展望瞭應用榦細胞分化的RPE移植的前景。
Schwartz등보고적용종인배태간세포분화성적시망막색소상피세포(RPE)이식치료시망막병,이관찰4월,상속성공。저시수차용종인배태간세포(hESC)정향분화이성적세포이식지환자취득성공。본문복습RPE이식적역사여현황;hESC분화이성적RPE(hESC-RPE)적실험연구이급림상이식적의의、방법、효과급존재문제,병전망료응용간세포분화적RPE이식적전경。
The first description of human embryonic stem cell-derived cells transplanted into human patients was reported by Schwartz et al, who performed the transplantation of hESC-derived retinal pigment epithelium (RPE) into the subretinal space in patients with retinal diseases and obtained successful results after 4 months’ observation. We review the past and present status of ocular pigment epithelium transplantation; the significance, methodology, results and problems of experimental and clinical hESC-derived RPE transplantation, and to discuss the strategies of using stem cell-derived RPE for the treatment of eye diseases.