国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2013年
16期
1240-1243
,共4页
吸烟%浆细胞样树突状细胞%髓样树突状细胞
吸煙%漿細胞樣樹突狀細胞%髓樣樹突狀細胞
흡연%장세포양수돌상세포%수양수돌상세포
Cigarette smoking%Plasmacytoid dendritic cell%Myeloid dendritic cell
目的 探讨吸烟对人外周血中树突状细胞(DCs)及其亚型比例及数量的影响.方法 选取25名吸烟者和21名不吸烟对照者,使用流式细胞术检测和计算外周血中DCs及其两种亚群浆细胞样树突状细胞(pDCs)和髓样树突状细胞(mDCs)所占比例和数量的变化.结果 与对照组比较,吸烟组外周血pDCs比例以及数量较对照组明显增高,mDCs无明显改变,mDCs/pDCs比值降低.结论 吸烟者外周血中起免疫耐受作用的pDCs数量增多,更容易患肿瘤和感染性疾病.
目的 探討吸煙對人外週血中樹突狀細胞(DCs)及其亞型比例及數量的影響.方法 選取25名吸煙者和21名不吸煙對照者,使用流式細胞術檢測和計算外週血中DCs及其兩種亞群漿細胞樣樹突狀細胞(pDCs)和髓樣樹突狀細胞(mDCs)所佔比例和數量的變化.結果 與對照組比較,吸煙組外週血pDCs比例以及數量較對照組明顯增高,mDCs無明顯改變,mDCs/pDCs比值降低.結論 吸煙者外週血中起免疫耐受作用的pDCs數量增多,更容易患腫瘤和感染性疾病.
목적 탐토흡연대인외주혈중수돌상세포(DCs)급기아형비례급수량적영향.방법 선취25명흡연자화21명불흡연대조자,사용류식세포술검측화계산외주혈중DCs급기량충아군장세포양수돌상세포(pDCs)화수양수돌상세포(mDCs)소점비례화수량적변화.결과 여대조조비교,흡연조외주혈pDCs비례이급수량교대조조명현증고,mDCs무명현개변,mDCs/pDCs비치강저.결론 흡연자외주혈중기면역내수작용적pDCs수량증다,경용역환종류화감염성질병.
Objective To investigate the effect of cigarette smoke on circulating dendritic cells (DCs) and their subsets.Methods The frequency and the absolute number of plasmacytoid dendritic cells (pDCs) and myeloid dendritic cells (mDCs) in peripheral blood of 25 smokers and 21 normal controls were determined by flow cytometry.Results Compared with normal controls,the frequency and absolute number of circulating pDCs increased,the frequency and the absolute number of circulating mDCs showed no change,and mDCs/pDCs reduced in smokers.Conclusions The number of pDCs is increased in peripheral blood of smokers,who are predisposed to suffer cancer and infectious disease.
