CAJ | 학술논문

　　目的：探讨小剂量他克莫司用于难治性全身型重症肌无力的疗效。方法：选择12例临床资料完整的难治性全身型重症肌无力患者，采用小剂量他克莫司进行治疗，分析患者的一般情况、Oosterhuis记分、MG-ADL评分、药物用量等。结果：9例坚持用药的患者Oosterhuis记分均明显减少；5例现生活自理，1例因股骨头坏死致行动困难，但肌力明显改善；5例住院次数减少，用药后8例患者使用激素量减低，1例为小剂量长期维持。结论：小剂量他克莫司治疗难治性全身型重症肌无力，可改善日常生活质量，减少激素用量。
　　목적：탐토소제량타극막사용우난치성전신형중증기무력적료효。방법：선택12례림상자료완정적난치성전신형중증기무력환자，채용소제량타극막사진행치료，분석환자적일반정황、Oosterhuis기분、MG-ADL평분、약물용량등。결과：9례견지용약적환자Oosterhuis기분균명현감소；5례현생활자리，1례인고골두배사치행동곤난，단기력명현개선；5례주원차수감소，용약후8례환자사용격소량감저，1례위소제량장기유지。결론：소제량타극막사치료난치성전신형중증기무력，가개선일상생활질량，감소격소용량。
Objective:To evaluate the efficacy of low-dose tacrolimus treatment on patients with refractory gener-alizedmyasthenia gravis (MG).Methods:Twelvecasesofrefractorygeneralized MG were treatedwithlowdose of FK-506. The clinical manifestation, Oosterhuis score, MG-ADL score and drugs usage were evaluated. Results:Oosterhuisscoreswasimproved in9 caseswith regular therapyofFK-506.Five cases could take care of themselves in daily life. Only 1 case was confined to bed because of femoral bone head necrosis, but the muscle strength im-proved significantly. The frequency of hospitalization was reduced in 5 cases. The doses of prednisolone were also reduced in 8 cases, and 1 case with long-term maintenance in low dose. Conclusion:Low-dose tacrolimus was ef-fective andsafe inthe treatmentofrefractorygeneralizedMG.