中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2013年
1期
38-41
,共4页
甲状腺乳头状癌%BFGF%BFGFR%侵袭%转移%免疫组织化学
甲狀腺乳頭狀癌%BFGF%BFGFR%侵襲%轉移%免疫組織化學
갑상선유두상암%BFGF%BFGFR%침습%전이%면역조직화학
Papillary thyroid carcinoma%BFGF%BFGFR%Invasion%Metastasis%Immunohistochemistry
目的 探讨碱性成纤维细胞生长因子(BFGF)及其受体(BFGFR)在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)的表达和相互关系.方法 应用免疫组化方法,对2001年3月至2005年5月在中国医科大学附属盛京医院手术并经病理组织学证实的PTC 80例,结节性甲状腺肿10例组织标本行BFGF、BFGFR表达研究.结果 BFGF及BFGFR阳性表达率在PTC组织中分别为72.5％ (58/80)及70.0％ (56/80)；在结节性甲状腺肿均为0.0％ (0/10),2者相比差异有统计学意义(P ＜0.05)；BFGF及BFGFR在PTC中的表达水平与患者性别、年龄、肿瘤大小无关(P＞0.05),与淋巴结转移和UICC定义的肿瘤分期相关(P＜0.05)；BFGF及BFGFR的表达呈正相关(r=0.330,P=0.003).结论 BFGF与BFGFR在PTC中呈高表达,在结节性甲状腺肿组织无表达；2者在PTC组织中的表达与淋巴结转移和UICC定义的肿瘤分期密切相关,可能参与肿瘤的发生、侵袭和转移.
目的 探討堿性成纖維細胞生長因子(BFGF)及其受體(BFGFR)在甲狀腺乳頭狀癌(papillary thyroid carcinoma,PTC)的錶達和相互關繫.方法 應用免疫組化方法,對2001年3月至2005年5月在中國醫科大學附屬盛京醫院手術併經病理組織學證實的PTC 80例,結節性甲狀腺腫10例組織標本行BFGF、BFGFR錶達研究.結果 BFGF及BFGFR暘性錶達率在PTC組織中分彆為72.5％ (58/80)及70.0％ (56/80)；在結節性甲狀腺腫均為0.0％ (0/10),2者相比差異有統計學意義(P ＜0.05)；BFGF及BFGFR在PTC中的錶達水平與患者性彆、年齡、腫瘤大小無關(P＞0.05),與淋巴結轉移和UICC定義的腫瘤分期相關(P＜0.05)；BFGF及BFGFR的錶達呈正相關(r=0.330,P=0.003).結論 BFGF與BFGFR在PTC中呈高錶達,在結節性甲狀腺腫組織無錶達；2者在PTC組織中的錶達與淋巴結轉移和UICC定義的腫瘤分期密切相關,可能參與腫瘤的髮生、侵襲和轉移.
목적 탐토감성성섬유세포생장인자(BFGF)급기수체(BFGFR)재갑상선유두상암(papillary thyroid carcinoma,PTC)적표체화상호관계.방법 응용면역조화방법,대2001년3월지2005년5월재중국의과대학부속성경의원수술병경병리조직학증실적PTC 80례,결절성갑상선종10례조직표본행BFGF、BFGFR표체연구.결과 BFGF급BFGFR양성표체솔재PTC조직중분별위72.5％ (58/80)급70.0％ (56/80)；재결절성갑상선종균위0.0％ (0/10),2자상비차이유통계학의의(P ＜0.05)；BFGF급BFGFR재PTC중적표체수평여환자성별、년령、종류대소무관(P＞0.05),여림파결전이화UICC정의적종류분기상관(P＜0.05)；BFGF급BFGFR적표체정정상관(r=0.330,P=0.003).결론 BFGF여BFGFR재PTC중정고표체,재결절성갑상선종조직무표체；2자재PTC조직중적표체여림파결전이화UICC정의적종류분기밀절상관,가능삼여종류적발생、침습화전이.
Objective To study the expression and clinical significance of BFGF factor(BFGF) and basic fibroblast growth factor receptor(BFGFR) in papillary thyroid carcinoma (PTC).Methods 80 casesof PTC and 10 cases of nodular goiter underwent surgical treatment from Mar.2001 to May.2005 in Shengjing Hospital of China Medical University.Samples were collected and immunohistochemistry staining was performed to detect the expression of BFGF and BFGFR.Results The expression rate of BFGF and BFGFR was 72.5％ (58/80)vs 70.0％ (56/80) in PTC,and 0.0％ (0/10) vs 0.0％ (0/10) in nodular goiter.The difference had statistical significance(P ＜0.05).The expression level of BFGF and BFGFR in PTC had no relation with sex,age or tumor size(P ＞0.05),but has relation with lymph node metastasis and UICC stage(P ＜0.05).The expression of BFGF was positively correlated with the expression of BFGFR (r =0.330,P =0.003).Conclusions BFGF and BFGFR are highly expressed in PTC but have no expression in nodular goiter or normal thyroid tissues.The expression of BFGF and BFGFR in PTC is closely related to lymph node metastasis and UICC stage,indicating the 2 may be involved in tumorigenesis,invasion,and metastasis.
