广东化工
廣東化工
엄동화공
GUANGDONG CHEMICAL INDUSTRY
2012年
9期
71-72,79
,共3页
丁清%洪伟勇%贠军贤%杨根生
丁清%洪偉勇%贠軍賢%楊根生
정청%홍위용%원군현%양근생
紫杉醇%微通道%固体脂质纳米粒
紫杉醇%微通道%固體脂質納米粒
자삼순%미통도%고체지질납미립
paclitaxel%microchannels%solid lipid nanoparticles(SLNs)
目的：制备载紫杉醇固体脂质纳米粒。方法：微通道内采用溶剂扩散法制备脂质纳米粒,并通过正交优化制备工艺。结果：制备的纳米粒稳定性良好,平均粒径为（129.87±2.91）nm,包封率为（3.11±0.06）%,载药率为（43.67±0.24）%。结论：本研究制备的载药固体脂质纳米粒载药特性与重复性良好。
目的：製備載紫杉醇固體脂質納米粒。方法：微通道內採用溶劑擴散法製備脂質納米粒,併通過正交優化製備工藝。結果：製備的納米粒穩定性良好,平均粒徑為（129.87±2.91）nm,包封率為（3.11±0.06）%,載藥率為（43.67±0.24）%。結論：本研究製備的載藥固體脂質納米粒載藥特性與重複性良好。
목적：제비재자삼순고체지질납미립。방법：미통도내채용용제확산법제비지질납미립,병통과정교우화제비공예。결과：제비적납미립은정성량호,평균립경위（129.87±2.91）nm,포봉솔위（3.11±0.06）%,재약솔위（43.67±0.24）%。결론：본연구제비적재약고체지질납미립재약특성여중복성량호。
Objective: To prepare paclitaxel loaded solid lipid nanoparticles(SLNs) with proper physicochemical property by rectangular microchannels.Methods: Paclitaxel loaded solid lipid nanoparticles(PTX-SLNs) was prepared by solvent diffusion method in rectangular microchannels.Orthogonal design was utilized to optimize prescription.Result: PTX-SLNs prepared with optimized prescription demonstrated good stability.The encapsulation efficiency and drug loading of PTX-SLNs were(43.67±0.24) % and(3.11±0.06) % respectively,the average size was(129.87±2.91) nm.Conclusion: PTX-SLNs has a good medicine characteristics and reproducibility.
