CAJ | 학술논문

目的：研究虫类中药蛴螬Holotrichia diomphalia Bates的化学成分。方法：采用各种色谱材料和技术（包括硅胶、RP-18反相硅胶、Sephadex LH-20、MCI gel CHP 20P、D101大孔吸附树脂柱色谱及高效液相色谱）,结合谱学方法（NMR、MS、ORD）分离鉴定蛴螬的化学成分。结果：从蛴螬的乙醇提取物中分离得到10个化合物,其结构经波谱鉴定为反-1,2-环己二醇（1）,甘油醇-1-单油酸酯（2）,水杨苷（3）,对甲氧基苯乙酸（4）,苯甲酸甘油-1-酯（5）,Yangjinhualine A（6）,（±）2-羟基戊二酸二甲酯（7）,邻羟基苯甲醇（8）,对羟基苯乙酸（9）和oxiran-2-ylmethano（l 10）。结论：化合物1~10均为首次从该种虫类中药中分离得到。
목적：연구충류중약제조Holotrichia diomphalia Bates적화학성분。방법：채용각충색보재료화기술（포괄규효、RP-18반상규효、Sephadex LH-20、MCI gel CHP 20P、D101대공흡부수지주색보급고효액상색보）,결합보학방법（NMR、MS、ORD）분리감정제조적화학성분。결과：종제조적을순제취물중분리득도10개화합물,기결구경파보감정위반-1,2-배기이순（1）,감유순-1-단유산지（2）,수양감（3）,대갑양기분을산（4）,분갑산감유-1-지（5）,Yangjinhualine A（6）,（±）2-간기무이산이갑지（7）,린간기분갑순（8）,대간기분을산（9）화oxiran-2-ylmethano（l 10）。결론：화합물1~10균위수차종해충충류중약중분리득도。
Objective: To investigate the chemical constituents of medicinal insects of Holotrichia diomphalia Bates.Methods: Various chromatography materials and technology(including silica gel,RP-18 reverse phase silica gel,Sephadex LH-20,MCI gel CHP 20P,D101 macroporous adsorption resin column chromatography and high performance liquid chromatography),combined with spectroscopic methods(NMR,MS,ORD) were applied to separate and identify the compourds of H.diomphalia Bates.Results: Ten compounds were isolated from H.diomphalia.Their structures were respectively identified as trans-1,2-cyclohexanediol(1),(9Z)glycerin-1-monooleate(2),salicin(3),4-methoxyphenyllacetic acid(4),glycerin-1-benzoate(5),yangjinhualine A(6),(±)dimerthyl-2((phenylmethoxy) methoxy) pentanedioate(7),salicyl alcohol(8),(p-hydroxyphenyl) acetic acid(9),and oxiran-2ylmethanol(10) by a suit of spectroscopic techniques.Conclusion: All the compounds were isolated from H.diomphalia for the first time.