CAJ | 학술논문

抗球虫新化合物纳川珠利的一般毒理学研究
항구충신화합물납천주리적일반독이학연구
General Toxicology Studies of a New Anticoccidial Compound Nitromezuril in Mice

万方数据

中国兽药杂志中國獸藥雜誌 중국수약잡지
CHINESE JOURNAL OF VETERINARY DRUG
2012年 10期 13-15 ,共3页

费陈忠%林洋%张涛%薛飞群%张可煜%张丽芳%王霄旸%孟新宇%王米%郑文丽%李涛

비진충%림양%장도%설비군%장가욱%장려방%왕소양%맹신우%왕미%정문려%리도

抗球虫化合物%纳川珠利%急性毒性%蓄积毒性抗毬蟲化閤物%納川珠利%急性毒性%蓄積毒性
항구충화합물%납천주리%급성독성%축적독성
anticoccidial compounds%nitromezuril%acute toxicity%cumulative toxicity

为评价新型抗球虫化合物纳川珠利的一般毒理学特性，选用昆明小鼠进行经口给药的急性毒性试验，以剂量递增法计算蓄积系数（K），于连续给药后第21天一次灌服1个LD50。剂量，观察各组小鼠对化合物的耐受性。结果显示，该化合物采用寇氏改良法计算的LD50为768mg／kg，95％可信限为644～916mg／kg；采用机率单位加权回归法（Bliss法）计算的LD50为769mg／kg，95％可信限为615～960mg／kg；计算的蓄积系数为4．26，中度蓄积；耐受性试验中试验组和对照组的小鼠死亡率差异无统计学意义（P〉0．05），小鼠对化合物的耐受性无明显变化。可初步认为该新化合物的毒性较低，在临床上应用相对安全，具有较好的成药性基础。
위평개신형항구충화합물납천주리적일반독이학특성，선용곤명소서진행경구급약적급성독성시험，이제량체증법계산축적계수（K），우련속급약후제21천일차관복1개LD50。제량，관찰각조소서대화합물적내수성。결과현시，해화합물채용구씨개량법계산적LD50위768mg／kg，95％가신한위644～916mg／kg；채용궤솔단위가권회귀법（Bliss법）계산적LD50위769mg／kg，95％가신한위615～960mg／kg；계산적축적계수위4．26，중도축적；내수성시험중시험조화대조조적소서사망솔차이무통계학의의（P〉0．05），소서대화합물적내수성무명현변화。가초보인위해신화합물적독성교저，재림상상응용상대안전，구유교호적성약성기출。
In order to assess the potential toxicity of new anticoccidial compound nitromezuril, the acute toxicity test of oral administration in mice was conducted. The accumulation factor (K) was calculated by gradually increasing doses. The amount of an LDs0 of mice was administrated on 21th to study the tolerance of mice to the compound. The results showed that the LDs0 of nitromezuril was 768 mg/kg and 769 mg/kg, 95% confidence interval was 644 -916 mg/kg and 615 -960 mg/kg by Kou's modified method and Bliss method respectively. The accumulative coefficient 4.26 was moderate accumulation. Mice mortality between test group and control group of tolerance test was no significant difference (P 〉 0.05 ). These results indicated that the new compound was less toxic and relatively safe in clinical application. Nitromezuril had good medicine foundation.