CAJ | 학술논문

为研究不同剂量恩诺沙星脂质纳米乳剂对断奶生长仔猪血液生化指标的影响，分别按0．6、1．25、2．5、5．0mg／kg剂量对仔猪进行给药，并在给药后2、6、8和96h前腔静脉采血制血清，测定仔猪谷草转氨酶（AST）、谷丙转氨酶（ALT）、碱性磷酸酶（ALP）、淀粉酶（AMY）、尿素（Urea）和肌酐（Crea）六项血液生化指标的含量。结果显示，四个不同剂量给药组的ALT、AST、ALP、AMY和Crea的含量在2、6、8和96h与对照组差异不显著（P〉0．05）；各剂量组的Urea在2h与对照组未见统计学差异，但5．0mg／kg剂量组在6h与对照组和0．6mg／kg剂量组差异显著（P〈0．05），在8h和96h时间点的数值与对照组和其他剂量组差异显著（P〈0．05）。试验表明，随着剂量的增加，恩诺沙星脂质纳米乳可能会对仔猪肾脏功能产生一定影响。
위연구불동제량은낙사성지질납미유제대단내생장자저혈액생화지표적영향，분별안0．6、1．25、2．5、5．0mg／kg제량대자저진행급약，병재급약후2、6、8화96h전강정맥채혈제혈청，측정자저곡초전안매（AST）、곡병전안매（ALT）、감성린산매（ALP）、정분매（AMY）、뇨소（Urea）화기항（Crea）륙항혈액생화지표적함량。결과현시，사개불동제량급약조적ALT、AST、ALP、AMY화Crea적함량재2、6、8화96h여대조조차이불현저（P〉0．05）；각제량조적Urea재2h여대조조미견통계학차이，단5．0mg／kg제량조재6h여대조조화0．6mg／kg제량조차이현저（P〈0．05），재8h화96h시간점적수치여대조조화기타제량조차이현저（P〈0．05）。시험표명，수착제량적증가，은낙사성지질납미유가능회대자저신장공능산생일정영향。
The study was conducted to investigate the effects of enrofloxacin - loaded lipid nanoemulsions on blood biochemical indices in weaned piglets. Each group was given enrofloxacin - loaded lipid nanoemulsions with 0.6, 1.25, 2.5 and 5.0 mg/kg by body weight, respectively. Blood samples were collected from anterior vena cava of all the piglets in 2, 6, 8 and 96 h. Test results showed that ALT, AST, ALP, AMY and Crea of four dose groups had no significant difference ( P 〉 0.05 ) with that of the control group in 2, 6, 8 and 96 hours. The urea of four close groups had no statistical difference with that of the control group in 2 hours ; the urea of the 5.0 mg/kg dose group in 6 hours was significantly different (P 〈 0.05 ) from that of the control group and that of the 0.6 mg/kg dose group, and the value of 8 hours and 96 hours also had significant difference (P 〈 0.05 ) with other groups. These results indicated that the enrofloxacin- loaded lipid nanoemulsions might have some influence on the renalfunction of the piglets with increasing dose.