CAJ | 학술논문

目的：观察参芪地黄降糖颗粒治疗早期糖尿病肾病（ DN）的临床疗效。方法将98例早期DN患者随机分为2组，均予常规治疗，治疗组52例加服参芪地黄降糖颗粒，对照组46例加服氯沙坦钾片，2组共治疗8周。观察2组治疗前后临床疗效，并记录2组治疗前后临床症状积分、尿蛋白排泄率（ UAER）、24 h尿蛋白定量、内生肌酐清除率（Ccr）、血尿素氮（BUN）及血肌酐（Cr）等。结果治疗组总有效率88．46％，对照组65．22％，差异有统计学意义（ P＜0．05）；治疗组治疗后临床症状积分、UAER、24 h尿蛋白定量、Ccr及Cr均下降，与对照组比较差异有统计学意义（P＜0．05），治疗组改善优于对照组。结论参芪地黄降糖颗粒可改善临床症状，延缓早期DN的进程，对DN有较好的防治作用。
목적：관찰삼기지황강당과립치료조기당뇨병신병（ DN）적림상료효。방법장98례조기DN환자수궤분위2조，균여상규치료，치료조52례가복삼기지황강당과립，대조조46례가복록사탄갑편，2조공치료8주。관찰2조치료전후림상료효，병기록2조치료전후림상증상적분、뇨단백배설솔（ UAER）、24 h뇨단백정량、내생기항청제솔（Ccr）、혈뇨소담（BUN）급혈기항（Cr）등。결과치료조총유효솔88．46％，대조조65．22％，차이유통계학의의（ P＜0．05）；치료조치료후림상증상적분、UAER、24 h뇨단백정량、Ccr급Cr균하강，여대조조비교차이유통계학의의（P＜0．05），치료조개선우우대조조。결론삼기지황강당과립가개선림상증상，연완조기DN적진정，대DN유교호적방치작용。
(P<0.05).After treatment, clinical symptom score and UAER, urinary protein, Ccr and serum creatinine (Cr) were decreased , as compared with the control group were statistically significant ( P<0 .05 ) .The improvement in the treatment group was better than that in the control group .Conclusion Shenqi Dihuang Jiangtang granule can im-prove the clinical symptoms, reduce early DN in patients with UAER, Ccr, Cr levels, delay of early DN process, has better therapeutic effects on DN .