重庆理工大学学报：自然科学
重慶理工大學學報：自然科學
중경리공대학학보：자연과학
Journal of Chongqing Institute of Technology
2012年
4期
33-39
,共7页
多肽%长效%化学修饰
多肽%長效%化學脩飾
다태%장효%화학수식
peptide%long-acting%chemical modification
多肽类药物在体内的半衰期较短,是影响其成药性的主要因素,因此解决这一问题成为多肽能否成药的关键。对延长多肽类药物在体内半衰期的化学修饰方法的原理和目前的研究现状进行综述。
多肽類藥物在體內的半衰期較短,是影響其成藥性的主要因素,因此解決這一問題成為多肽能否成藥的關鍵。對延長多肽類藥物在體內半衰期的化學脩飾方法的原理和目前的研究現狀進行綜述。
다태류약물재체내적반쇠기교단,시영향기성약성적주요인소,인차해결저일문제성위다태능부성약적관건。대연장다태류약물재체내반쇠기적화학수식방법적원리화목전적연구현상진행종술。
Short half-time is the main factor that restricts peptides becoming effective drugs. To solve this problem is the key for peptides to change into drugs. The research of peptide drugs long-acted technology and long-acting peptide drugs has turned into a new and hot field, causing wide concern The paper summarized the chemical modification methods about prolonging peptide drugs half-life, in- cluding their principle and present research situation.
