CAJ | 학술논문

α-硫辛酸及其还原态二氢硫辛酸具有极强的抗氧化性,可改善葡萄糖代谢,减弱氧化应激,对糖尿病性白内障、糖尿病多发性神经病及心血管损伤等糖尿病并发症具有较好的预防和治疗作用。概述了α-硫辛酸的作用机制、生物合成途径及应用,重点综述了具有良好应用前景的生物法生产α-硫辛酸工艺。
α-류신산급기환원태이경류신산구유겁강적항양화성,가개선포도당대사,감약양화응격,대당뇨병성백내장、당뇨병다발성신경병급심혈관손상등당뇨병병발증구유교호적예방화치료작용。개술료α-류신산적작용궤제、생물합성도경급응용,중점종술료구유량호응용전경적생물법생산α-류신산공예。
Alpha-lipoic acid and its reduced dihydrolipoic acid have strong antioxidative activity, they could improve glucose metabolism, diminish oxidative stress, and could prevent and treat diabetic cataract, diabetic polyneuropathy, cardiovascular damage and other complications of diabetes. α-Lipoic acid＇s mechanism of α- tion, biosynthetic pathway of α-lipoic acid, and its application, especially the biological production of α-lipoic acid which has broad prospects for application development were reviewed in this paper.