广东化工
廣東化工
엄동화공
GUANGDONG CHEMICAL INDUSTRY
2012年
7期
50-51
,共2页
李娅生%刘大勇%王九%王昱航%陈强%付富生
李婭生%劉大勇%王九%王昱航%陳彊%付富生
리아생%류대용%왕구%왕욱항%진강%부부생
乙酰水杨酸:对甲苯磺酸%乙酸酐
乙酰水楊痠:對甲苯磺痠%乙痠酐
을선수양산:대갑분광산%을산항
acetylsalicylic acid concentrated%4-Toluene sulfonic acid: acetic anhydride
对乙酰水杨酸“老药新用”的应用现状以及应用前景进行了详细的分析。比较了目前市场上乙酰水杨酸各种合成方法的优劣,设计了适合于工业化的较佳的合成路线,考察了原料物质的量之比、催化剂用量、反应温度、反应时间对反应收率的影响,进一步优化了合成工艺。经过实验数据的处理与分析,采用O-酰基化反应合成乙酰水杨酸的适宜条件为:无水环境下,对甲苯磺酸为催化剂,n(水杨酸):n(乙酸酹)=1:2.0:反应温度为85℃和反应时间为30rain时,乙酰水杨酸的收率高于97%。所得样品符合《中国药典》和《美国药典》中乙酰水杨酸的质量要求,能够用于合成乙酰水杨酸。
對乙酰水楊痠“老藥新用”的應用現狀以及應用前景進行瞭詳細的分析。比較瞭目前市場上乙酰水楊痠各種閤成方法的優劣,設計瞭適閤于工業化的較佳的閤成路線,攷察瞭原料物質的量之比、催化劑用量、反應溫度、反應時間對反應收率的影響,進一步優化瞭閤成工藝。經過實驗數據的處理與分析,採用O-酰基化反應閤成乙酰水楊痠的適宜條件為:無水環境下,對甲苯磺痠為催化劑,n(水楊痠):n(乙痠酹)=1:2.0:反應溫度為85℃和反應時間為30rain時,乙酰水楊痠的收率高于97%。所得樣品符閤《中國藥典》和《美國藥典》中乙酰水楊痠的質量要求,能夠用于閤成乙酰水楊痠。
대을선수양산“로약신용”적응용현상이급응용전경진행료상세적분석。비교료목전시장상을선수양산각충합성방법적우렬,설계료괄합우공업화적교가적합성로선,고찰료원료물질적량지비、최화제용량、반응온도、반응시간대반응수솔적영향,진일보우화료합성공예。경과실험수거적처리여분석,채용O-선기화반응합성을선수양산적괄의조건위:무수배경하,대갑분광산위최화제,n(수양산):n(을산뢰)=1:2.0:반응온도위85℃화반응시간위30rain시,을선수양산적수솔고우97%。소득양품부합《중국약전》화《미국약전》중을선수양산적질량요구,능구용우합성을선수양산。
Acetylsalicylic acid "new use for an old drug" application status and application prospect were analyzed in detail. Compared with the present market of acetylsalicylic acid synthesis methods advantages and disadvantages. Design suitable for industrialization of better synthetic route. The effect of raw material ratio, the dosage of catalyst, reaction temperature, reaction time on the yield of the reaction, further optimization of the synthesis technology. Through the experimental data processing and analysis, the O acylation reaction conditions for synthesis of acetyl salicylic acid: without water environment, concentrated 4-Toluene sulfonic acid as catalyst, n(salicylic acid) " n(acetic anhydride)=l : 2.0; when the reaction temperature of 85 ℃ and reaction time of 30 min, acetyl salicylic acid yield were higher than 97 %. The sample meets acetylsalicylic acid quality requirements of"Chinese Pharmacopoeia" and "with the United States Pharmacopoeia", can be used for the synthesis of acetyl salicylic acid.