CAJ | 학술논문

喹烯酮是国家的一类新型兽药。由于其在生物体内的利用率低，喹烯酮代谢物1-（3-甲基喹喔啉-2-基）-3-苯基2-丙烯-1-醇难于从生物的排泄物中分离与鉴定。文章以喹烯酮为原料，经三氯化磷以及四氢锂铝还原后，首次合成喹烯酮的代谢物1-（3-甲基喹喔啉-2-基）-3-苯慕2-丙烯-1-醇，两步收率达75％。各步化合物经高效液相色谱、质谱、氢核磁谱等分析手段，验证结构符合。
규희동시국가적일류신형수약。유우기재생물체내적이용솔저，규희동대사물1-（3-갑기규악람-2-기）-3-분기2-병희-1-순난우종생물적배설물중분리여감정。문장이규희동위원료，경삼록화린이급사경리려환원후，수차합성규희동적대사물1-（3-갑기규악람-2-기）-3-분모2-병희-1-순，량보수솔체75％。각보화합물경고효액상색보、질보、경핵자보등분석수단，험증결구부합。
Quincetone is a new class of veterinary drugs. For low bioavailablity of quinocetone in animals, it is difficult to separate and identify the metabolite of quinocetone from excreta. A method for synthesis of the metabolites of quincetone was reported. We got the target compound of 1-（3-methylquinoxalin-2-yl）-3-phenylprop-2-en-1-ol by reducing with phosphorus trichloride and lithium aluminum hydride for the first time. The two steps were prepared with overall yield of 75 %. The title compounds ware confirmed with HPLC, MS, 1H-NMR et al.