河北联合大学学报(医学版)
河北聯閤大學學報(醫學版)
하북연합대학학보(의학판)
JOURNAL OF NORTH CHINA COAL MEDICAL UNIVERSITY
2014年
2期
143-145
,共3页
陈守中%王志文%王国权%彭博
陳守中%王誌文%王國權%彭博
진수중%왕지문%왕국권%팽박
抗骨增生片%骨关节炎%滑膜%超氧化物歧化酶%一氧化氮
抗骨增生片%骨關節炎%滑膜%超氧化物歧化酶%一氧化氮
항골증생편%골관절염%활막%초양화물기화매%일양화담
Kangguzengsheng tablet%Osteoarthritis%Synovium%SOD%NO
①目的观察抗骨增生片对兔膝骨关节炎滑膜组织病理形态及滑膜组织中超氧化物歧化酶( SOD)、一氧化氮( NO)表达的影响。②方法将30只健康雄性日本大耳白兔随机分为正常对照组( A)10只,造模组20只。造模组白兔于膝关节腔内注射1.6%木瓜蛋白酶造成兔膝骨关节炎模型。将造模成功的造模组随机分为模型对照组( B)、抗骨增生片组C(B,C, n =10),C组灌胃(ig)给予0.36 gk/g 的抗骨增生片,1次/d;A ,B组每日ig给予等量生理盐水。30d 后,取膝关节,用 HE染色观察滑膜组织病理形态,用免疫组织化学法检测滑膜组织中SOD, NO的表达情况。③结果抗骨增生片组滑膜组织破坏程度较模型组明显减轻;SOD在抗骨增生片组中表达均较模型组显著升高( P <0.01或P <0.05),NO在抗骨增生片组中表达均较模型组显著降低( P <0.01或P <0.05)。④结论抗骨增生片能抑制骨关节炎滑膜炎症发展,修复损伤滑膜可能与其改善骨关节炎滑膜组织病理损害,与上调 SOD,下调NO的表达有关。
①目的觀察抗骨增生片對兔膝骨關節炎滑膜組織病理形態及滑膜組織中超氧化物歧化酶( SOD)、一氧化氮( NO)錶達的影響。②方法將30隻健康雄性日本大耳白兔隨機分為正常對照組( A)10隻,造模組20隻。造模組白兔于膝關節腔內註射1.6%木瓜蛋白酶造成兔膝骨關節炎模型。將造模成功的造模組隨機分為模型對照組( B)、抗骨增生片組C(B,C, n =10),C組灌胃(ig)給予0.36 gk/g 的抗骨增生片,1次/d;A ,B組每日ig給予等量生理鹽水。30d 後,取膝關節,用 HE染色觀察滑膜組織病理形態,用免疫組織化學法檢測滑膜組織中SOD, NO的錶達情況。③結果抗骨增生片組滑膜組織破壞程度較模型組明顯減輕;SOD在抗骨增生片組中錶達均較模型組顯著升高( P <0.01或P <0.05),NO在抗骨增生片組中錶達均較模型組顯著降低( P <0.01或P <0.05)。④結論抗骨增生片能抑製骨關節炎滑膜炎癥髮展,脩複損傷滑膜可能與其改善骨關節炎滑膜組織病理損害,與上調 SOD,下調NO的錶達有關。
①목적관찰항골증생편대토슬골관절염활막조직병리형태급활막조직중초양화물기화매( SOD)、일양화담( NO)표체적영향。②방법장30지건강웅성일본대이백토수궤분위정상대조조( A)10지,조모조20지。조모조백토우슬관절강내주사1.6%목과단백매조성토슬골관절염모형。장조모성공적조모조수궤분위모형대조조( B)、항골증생편조C(B,C, n =10),C조관위(ig)급여0.36 gk/g 적항골증생편,1차/d;A ,B조매일ig급여등량생리염수。30d 후,취슬관절,용 HE염색관찰활막조직병리형태,용면역조직화학법검측활막조직중SOD, NO적표체정황。③결과항골증생편조활막조직파배정도교모형조명현감경;SOD재항골증생편조중표체균교모형조현저승고( P <0.01혹P <0.05),NO재항골증생편조중표체균교모형조현저강저( P <0.01혹P <0.05)。④결론항골증생편능억제골관절염활막염증발전,수복손상활막가능여기개선골관절염활막조직병리손해,여상조 SOD,하조NO적표체유관。
Objective To explore whether effect of Kangguzengsheng Tablet is related to the synovium conformation change and the regulation of SOD and NO .Methods 30 healthy male rabbits were randomly divided into the normal control group , the model control group and the Kangguzengsheng Tablet group .The KOA model were induced by injection 1.6﹪papain into the cavum articulare.After intragastric administration for 4 weeks, the synovium pathomorphology change and the expressions of SOD and NO were observed .Results Kangguzengsheng tablet group of synovial tissue damage was significantly reduced compared with model group;the expression of SOD in Kangguzengsheng tablet group than in model group increased significantly ( P<0.01 orP <0.05), the expression of NO in Kangguzengsheng tablet group were significantly lower than the model group ( P <0.01orP <0.05).Con-clusion Kangguzengsheng tablet can inhibit bone arthritis synovitis , synovial membrane repair damage may be related to improving pathological damage , synovium of osteoarthritis upregulation of SOD , down regulate the expression of NO.