CAJ | 학술논문

目的：观察氨氯地平、培哚普利治疗高血压的效果和安全性。方法选取42例高血压患者给予氨氯地平、培哚普利联合治疗，通过24 h动态血压监测评估治疗4周后患者治疗效果。结果治疗4周后患者收缩压、舒张压均低于治疗前，差异均有统计学意义（P＜0．05）。治疗4周后患者24 h、白昼、夜间的收缩压和舒张压均低于治疗前，差异均有统计学意义（ P＜0．05）。结论氨氯地平、培哚普利可以有效地降低血压水平，减轻血压负荷。
목적：관찰안록지평、배타보리치료고혈압적효과화안전성。방법선취42례고혈압환자급여안록지평、배타보리연합치료，통과24 h동태혈압감측평고치료4주후환자치료효과。결과치료4주후환자수축압、서장압균저우치료전，차이균유통계학의의（P＜0．05）。치료4주후환자24 h、백주、야간적수축압화서장압균저우치료전，차이균유통계학의의（ P＜0．05）。결론안록지평、배타보리가이유효지강저혈압수평，감경혈압부하。
Objective To investigate the effect and safety of amlodipine and perindopril in the pa-tients with hypertension .Methods 42 hypertensive patients were treated with amlodipine and perindo-pril for 4 weeks .ABPM was conducted at the end of placebo baseline and the end of 4 weeks .Results After 4 weeks of treatment in patients with systolic blood pressure ,diastolic blood pressure was(121 . 8 ± 10 .5) ,(84 .3 ± 4 .5)mmHg ,was lower than that before treatment ,the differences were statistical-ly significant (P<0 .05) .After 4 weeks of treatment in patients with 24h ,daytime ,nighttime systolic and diastolic blood pressure were lower than those before treatment ,the differences were statistically significant (P<0 .05) .Conclusion Amlodipine and perindopril can effectively reduced the ambulatory blood pressure and blood pressure loadduring the time of 24 hours in essential hypertension .