CAJ | 학술논문

目的：研究小儿脑脊液和血清S100B蛋白、β2微球蛋白（β2-MG）、C反应蛋白（CRP）及补体C3、C4含量与细菌性脑膜炎（BM ）和病毒性脑炎（VE）的关系，探讨联合检测该5项指标对小儿BM和VE的诊断意义。方法分别检测BM 18例、VE 22例和对照组21例患儿的脑脊液及血清上述5项指标。结果⑴BM组和VE组脑脊液S100B蛋白含量均明显高于对照组（P＜0．05）；但BM组脑脊液S100B蛋白含量和VE组比较，差异无显著性。⑵BM 组和VE组脑脊液β2-MG含量均明显高于对照组（P＜0．05），其中BM组脑脊液β2-MG含量明显高于VE组（P＜0．05）。⑶BM 组脑脊液C3含量明显高于VE及对照组（P＜0．05），VE组C3含量和对照组比较差异无显著性。⑷各组血清S100B蛋白、β2-M G、CRP、C3、C4含量及脑脊液CRP、C4含量比较差异无显著性。结论⑴BM 和V E的脑脊液S100B蛋白、β2-M G、C3含量较血清学指标敏感，提示脑脊液S100B蛋白、β2-M G可以作为脑损伤的标志物。未提示脑脊液S100B蛋白含量对V E和BM具有早期鉴别诊断意义。⑵脑脊液β2-M G可以作为BM的鉴别诊断参考指标。⑶联合检测脑脊液β2-M G、补体C3，有助于鉴别BM和V E ，特别是能提高BM诊断的准确性。⑷未发现血清S100B蛋白、β2-M G、补体C3、脑脊液及血清补体C4、CRP对BM和VE诊断的提示意义。
목적：연구소인뇌척액화혈청S100B단백、β2미구단백（β2-MG）、C반응단백（CRP）급보체C3、C4함량여세균성뇌막염（BM ）화병독성뇌염（VE）적관계，탐토연합검측해5항지표대소인BM화VE적진단의의。방법분별검측BM 18례、VE 22례화대조조21례환인적뇌척액급혈청상술5항지표。결과⑴BM조화VE조뇌척액S100B단백함량균명현고우대조조（P＜0．05）；단BM조뇌척액S100B단백함량화VE조비교，차이무현저성。⑵BM 조화VE조뇌척액β2-MG함량균명현고우대조조（P＜0．05），기중BM조뇌척액β2-MG함량명현고우VE조（P＜0．05）。⑶BM 조뇌척액C3함량명현고우VE급대조조（P＜0．05），VE조C3함량화대조조비교차이무현저성。⑷각조혈청S100B단백、β2-M G、CRP、C3、C4함량급뇌척액CRP、C4함량비교차이무현저성。결론⑴BM 화V E적뇌척액S100B단백、β2-M G、C3함량교혈청학지표민감，제시뇌척액S100B단백、β2-M G가이작위뇌손상적표지물。미제시뇌척액S100B단백함량대V E화BM구유조기감별진단의의。⑵뇌척액β2-M G가이작위BM적감별진단삼고지표。⑶연합검측뇌척액β2-M G、보체C3，유조우감별BM화V E ，특별시능제고BM진단적준학성。⑷미발현혈청S100B단백、β2-M G、보체C3、뇌척액급혈청보체C4、CRP대BM화VE진단적제시의의。
Objective To investigate the relationship between cerebrospina1 fluid (CSF) and ser-um level of S100B protein ,β2-microglobulin (β2-MG) ,C-reactive protein (CRP) and complement C3 , C4 in pediatric patients with bacterial meningitis (BM) and viral encephalitis (VE) .To research the value of combination detection the five index in pediatric patients with BM and VE .Methods The level of above-mentioned five indexes in CSF and serum were detected in three groups which were 18 BM , 22 VE and 21 control groups .Results CSF level of S100B protein in BM and VE were significant high-er than those of control group ,P<0 .05 ,and there was no significant deviation in CSF level of S100B between the group of BM and VE .CSF level of β2-MG in BM and VE were significant higher than those of control group ,P<0 .05 ,and CSF level ofβ2-MG in BM were significant higher than those of VE ,P<0 .05 .CSF level of complement C3 in BM were significant higher than those of VE and con-trol group ,P<0 .05 ,there was no significant deviation in the CSF level of complement C3 between the groups of VE and control .There was no significant deviation in the serum level of S100B ,β2-MG , CRP ,C3 ,C4 in groups of BM ,VE and control .There was no significant deviation in the CSF level of CRP ,C4 in groups of BM ,VE and control .Conclusion CSF level of β2-MG ,S100B protein and com-plement C3 was sensitive index of diagnosis than serum level in BM and VE .β2-MG and S100B protein of CSF may become marker of brain damage .CSF level of S100B protein had no value of differential diagnosis in BM and VE .CSF level of β2-MG may become the reference index of differential diagnosis in BM .Combination detection in CSF level of β2-MG and complement C3 contribute to identify BM and VE ,and may elevate the accuracy of diagnosis in BM .The serum level of S100B protein ,β2-MG , complement C3 ,and the CSF and serum level of complement C4 ,CRP has no diagnosis value in BM and VE.