CAJ | 학술논문

目的：分析比较原发性肝细胞癌（hepatocel ular carcinoma,HCC）患者血清AFP、CA199、CA125水平，找出它们之间的相关性。方法选择2007年3月～2013年10月在我院肝胆外科、肿瘤科治疗的138例HCC患者，及同院内科、传染科治疗的50例肝硬化、乙型肝炎患者和100名健康体检者，用化学发光法对血清AFP、CA199、CA125进行检测和比较分析。结果138例HCC患者AFP阳性率73.9%、CA199阳性率69.6%、CA125阳性率65.2%；AFP阴性的HCC患者中， CA199和CA125有较高的阳性率，经手术治疗后，均明显降低，经放化疗，有些升高，有些降低。结论 AFP与CA199、CA125联合检测，可明显提高HCC阳性诊断率，特别对AFP阴性的HCC患者，检测CA199、CA125不仅可作为诊断的参考指标，而且可作为疗效观察，预后评估和复发监测的重要指标。
목적：분석비교원발성간세포암（hepatocel ular carcinoma,HCC）환자혈청AFP、CA199、CA125수평，조출타문지간적상관성。방법선택2007년3월～2013년10월재아원간담외과、종류과치료적138례HCC환자，급동원내과、전염과치료적50례간경화、을형간염환자화100명건강체검자，용화학발광법대혈청AFP、CA199、CA125진행검측화비교분석。결과138례HCC환자AFP양성솔73.9%、CA199양성솔69.6%、CA125양성솔65.2%；AFP음성적HCC환자중， CA199화CA125유교고적양성솔，경수술치료후，균명현강저，경방화료，유사승고，유사강저。결론 AFP여CA199、CA125연합검측，가명현제고HCC양성진단솔，특별대AFP음성적HCC환자，검측CA199、CA125불부가작위진단적삼고지표，이차가작위료효관찰，예후평고화복발감측적중요지표。
Objective Through analysis and comparison of AFP , CA199, CA125 level in serum of primary hepatocellular carcinoma (HCC) patients, to identify the correlation between them. Methods A total of 138 serum samples from HCC patients of Hepatobiliary and Oncology , 50 serum samples from patients with Cirrhosis and Hepatitis B from Medicine department and infectious department and 100 serum samples of healthy people were obtained from March 2007 to October 2007. Al samples were detected and compared by using chemiluminescence. Results In 138 serum samples from HCC patients, AFP showed 73.9% of positive rate, CA199 showed 69.9% of positive rate, CA125 showed 65.2% of positive rate. In serum samples of AFP -negative HCC patients, CA199 and CA125 had a higher positive rate. After surgery, they were significantly reduced. After chemotherapy, some were elevated and some were reduced. Conclusion Combined detection of AFP , CA199 and CA125 can significantly improve the diagnostic yield of positive HCC. Especial y for AFP -negative HCC patients, detection of CA199 and CA125 can not only be used as a reference for the diagnosis, but also as an important indicator of efficacy, prognosis and recurrence monitoring .