CAJ | 학술논문

目的：评价免疫相关鸟苷三磷酸酶基因（IRGM）多态性与克罗恩病（CD）易感性的关系。方法用主题词或关键词检索Cochrane图书馆、Pubmed、Embase、ISI数据库、中文科技期刊数据库、中国期刊全文数据库，万方数据库以获得相关研究，检索时间从建库至2012年10月。根据纳入和排除标准由两名研究者独立进行文献质量评价，使用Review Manager 5.2.6统计软件进行Meta分析，效应量为比值比（OR）。结果共有9个病例-对照研究和队列研究纳入分析。Meta分析结果显示在IRGM-4958847 A/G多态性位点，杂合子AG与野生型相比，合并效应量OR=1.17，95%CI（1.01～1.35）， P=0.03。结论 IRGM-4958847位点AG型基因可能与CD遗传易感性相关。
목적：평개면역상관조감삼린산매기인（IRGM）다태성여극라은병（CD）역감성적관계。방법용주제사혹관건사검색Cochrane도서관、Pubmed、Embase、ISI수거고、중문과기기간수거고、중국기간전문수거고，만방수거고이획득상관연구，검색시간종건고지2012년10월。근거납입화배제표준유량명연구자독립진행문헌질량평개，사용Review Manager 5.2.6통계연건진행Meta분석，효응량위비치비（OR）。결과공유9개병례-대조연구화대렬연구납입분석。Meta분석결과현시재IRGM-4958847 A/G다태성위점，잡합자AG여야생형상비，합병효응량OR=1.17，95%CI（1.01～1.35）， P=0.03。결론 IRGM-4958847위점AG형기인가능여CD유전역감성상관。
Objective To investigate the association between immunity-related GTPase family M(IRGM)gene polymorphisms and genetic susceptibility to Crohn's disease(CD).Methods MeSH and keyword searches of the Cochrane Database, Pubmed, Embase, Science Citation Index, the Database of Chinese Science Journals,Full-text Database of Chinese Journals,and Wanfang Database from the inception of each database to October 2012 were performed to identify all available studies. Two independent reviewers assessed studies for inclusion and exclusion based on methodological quality criteria, and then conducted Meta-analysis of(Odds ratio,OR)using Review Manager 5.2.6 software.Results A total of nine case-control or cohort studies were included. Meta-analyses showed for the IRGM-4958847 A/G gene polymorphism, the AG genotype was associated with the risk of CD(OR=1.17,95%CI(1.01-1.35),P=0.03).Conclusion The meta-analysis suggests that the IRGM-4958847 AG genotype might be a risk factor for CD.