西北药学杂志
西北藥學雜誌
서북약학잡지
2014年
1期
64-67
,共4页
张亮%侯文洁%李梓源%白龙翔%厉廷有
張亮%侯文潔%李梓源%白龍翔%厲廷有
장량%후문길%리재원%백룡상%려정유
(S)-2 ,6-二甲基苯丙氨酸%Ni(Ⅱ)螯合物%合成
(S)-2 ,6-二甲基苯丙氨痠%Ni(Ⅱ)螯閤物%閤成
(S)-2 ,6-이갑기분병안산%Ni(Ⅱ)오합물%합성
(S)-2,6-dimethylphenylalanine%chiral Ni(Ⅱ)complex%synthesis
目的：合成非天然氨基酸(S)-2,6-二甲基苯丙氨酸。方法2,6-二甲基苯甲酸经还原得到2,6-二甲基苯甲醇,再溴化生成2,6-二甲基溴苄,2,6-二甲基溴苄与(S)-BPB-Ni-Gly络合物缩合,经分离后得到(S)-Tmp-BPB-Ni 络合物,经酸解后得到(S)-2,6-二甲基苯丙氨酸。结果以33.6%的总收率得到目标产物(S)-2,6-二甲基苯丙氨酸。结论该方法具有原料廉价、易得、反应条件温和等优点。
目的：閤成非天然氨基痠(S)-2,6-二甲基苯丙氨痠。方法2,6-二甲基苯甲痠經還原得到2,6-二甲基苯甲醇,再溴化生成2,6-二甲基溴芐,2,6-二甲基溴芐與(S)-BPB-Ni-Gly絡閤物縮閤,經分離後得到(S)-Tmp-BPB-Ni 絡閤物,經痠解後得到(S)-2,6-二甲基苯丙氨痠。結果以33.6%的總收率得到目標產物(S)-2,6-二甲基苯丙氨痠。結論該方法具有原料廉價、易得、反應條件溫和等優點。
목적：합성비천연안기산(S)-2,6-이갑기분병안산。방법2,6-이갑기분갑산경환원득도2,6-이갑기분갑순,재추화생성2,6-이갑기추변,2,6-이갑기추변여(S)-BPB-Ni-Gly락합물축합,경분리후득도(S)-Tmp-BPB-Ni 락합물,경산해후득도(S)-2,6-이갑기분병안산。결과이33.6%적총수솔득도목표산물(S)-2,6-이갑기분병안산。결론해방법구유원료렴개、역득、반응조건온화등우점。
Objective To synthesize the unnatural amino acid (S)-2,6-dimethylphenylalanine.Methods 2,6-Dimethylbenzoic acid was reduced to produce 2,6-dimethylbenzyl alcohol,then the alcohol was brominated to generate 2,6-dimethylbenzy bromide.The bromide was then coupled with (S)-BPB-Ni-Gly complex to give (S)-Dmp-BPB-Ni complex,which was then decomposed by acid to obtain (S)-2,6-dimethylphenylalanine.Results (S)-2,6-dimethylphenylalanine was synthesized at a total yield of 33.6%.Con-clusion This method has characteristics of cheap starting material and simple experimental procedure.
