CAJ | 학술논문

目的：研究 tempol氮氧自由基的酚类衍生物对辐射细胞及小鼠损伤的保护作用。方法合成了4种兼具 tempol 氮氧自由基和酚羟基的化合物,比较它们对肿瘤细胞和正常细胞的辐射防护作用,并进一步测定被辐照小鼠外周血的白细胞数(WBC)、中性粒细胞数(ANC)、单核细胞数(AMC)、血小板数(platelet count)等指标。结果合成并表征了4个 tempol 酚类衍生物结构。与 tempol相比,辐射小鼠的 WBC,ANC,AMC,血小板数具有不同程度的改善。结论稳定的氮氧自由基是一类较好的抗氧化损伤药物,tempol的酚类衍生物在细胞和动物水平均显示了较好的辐射防护能力。
목적：연구 tempol담양자유기적분류연생물대복사세포급소서손상적보호작용。방법합성료4충겸구 tempol 담양자유기화분간기적화합물,비교타문대종류세포화정상세포적복사방호작용,병진일보측정피복조소서외주혈적백세포수(WBC)、중성립세포수(ANC)、단핵세포수(AMC)、혈소판수(platelet count)등지표。결과합성병표정료4개 tempol 분류연생물결구。여 tempol상비,복사소서적 WBC,ANC,AMC,혈소판수구유불동정도적개선。결론은정적담양자유기시일류교호적항양화손상약물,tempol적분류연생물재세포화동물수평균현시료교호적복사방호능력。
Obj ective To investigate the bioactivity of tempol-phenol conj ugates on radiation-induced damage in cells and irradiated mice.Methods Four compounds with both tempol and phenol substructure were synthesized.Their protective effect on normal cells compared to tumor cells was evaluated.Their effect on peripheral WBC,ANC,AMC and platelet counts in an rat model invi-vo was determined.Results The four conjugated derivatives were prepared and characterized.Invivo study showed that compared to the tempol group,the compounds treated group had greater recovery in WBC,ANC,AMC and platelet count.Conclusion Stable nitroxides are the potential antioxidant drugs.The Tempol-phenol conj ugates have an improved radiation protect activity both in cells and mice.And further research on the mechanism should be taken into consideration.