CAJ | 학술논문

目的探讨慢性阻塞性肺疾病(COPD)患者血清白介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平与肺功能相关性的临床意义.方法选取我院收治的COPD患者84例和健康体检者45例.血常规检测外周血中性粒细胞占白细胞总数百分比(Neu/Leu％),采用ELISA方法测定COPD患者和健康体检者血清IL-6和TNF-α浓度,同时计算第1秒用力呼气容积占预计值百分比(FEV1 ％pred)检测肺功能指标.结果 COPD稳定期组、急性加重期组的外周血Neu/Leu％,血清IL-6、TNF-α水平均高于对照组,急性加重期组较稳定期组进一步升高,差异均有统计学意义(P＜0.05).FEV1％ pred值在正常对照组以及COPD稳定期组、急性加重期组则呈递减趋势,组间两两比较差异均有统计学意义(P＜0.05).血清IL-6、TNF-α水平与FEV1％ pred均呈负相关(P＜0.05),与Neu/Leu％均呈正相关(P＜0.05).结论 IL-6、TNF-α、中性粒细胞密切参与了COPD的炎症反应过程,与肺功能密切相关,可作为评估病情严重程度的辅助指标.
목적 탐토만성조새성폐질병(COPD)환자혈청백개소6(IL-6)、종류배사인자α(TNF-α)수평여폐공능상관성적림상의의.방법 선취아원수치적COPD환자84례화건강체검자45례.혈상규검측외주혈중성립세포점백세포총수백분비(Neu/Leu％),채용ELISA방법측정COPD환자화건강체검자혈청IL-6화TNF-α농도,동시계산제1초용력호기용적점예계치백분비(FEV1 ％pred)검측폐공능지표.결과 COPD은정기조、급성가중기조적외주혈Neu/Leu％,혈청IL-6、TNF-α수평균고우대조조,급성가중기조교은정기조진일보승고,차이균유통계학의의(P＜0.05).FEV1％ pred치재정상대조조이급COPD은정기조、급성가중기조칙정체감추세,조간량량비교차이균유통계학의의(P＜0.05).혈청IL-6、TNF-α수평여FEV1％ pred균정부상관(P＜0.05),여Neu/Leu％균정정상관(P＜0.05).결론 IL-6、TNF-α、중성립세포밀절삼여료COPD적염증반응과정,여폐공능밀절상관,가작위평고병정엄중정도적보조지표.
Objective To explore the relationship between the serum interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α) levels and the lung function in chronic obstructive pulmonary disease (COPD) patients.Methods Eighty-four patients with COPD and 45 normal subjects were involved in the study.The pulmonary function and the ratio of neutrophils/leukocytes (Neu/Leu％) were tested in all these cases.The serum IL-6,TNF-α level was measured by ELISA.Results The levels of Neu/Leu％,IL-6,TNF-α were decreased obviously in remission period (P ＜ 0.05),while FEV1 ％ pred was significantly lower in AECOPD than in remission period (P ＜0.05).The levels of IL-6,TNF-α presented notably negative correlation to FEV1 ％ pred (P ＜0.05).The levels of IL-6,TNF-α presented notably positive correlation to Neu/Leu％ (P ＜0.05).Conclusions The IL-6,TNF-α are involved in airway inflammation and the pathogenic process of COPD,and may influence the lung function.