CAJ | 학술논문

TCF7L2基因rs7903146T/C和rs7901695T/C单核苷酸多态性与内蒙古汉族人群2型糖尿病易感性的相关性研究
TCF7L2기인rs7903146T/C화rs7901695T/C단핵감산다태성여내몽고한족인군2형당뇨병역감성적상관성연구
Study on the relation of TCF7L2 rs7903146T/C and rs7901695T/C SNPs with susceptibility to Type 2 Diabetes mellitus in Inner Mongolia Han people

万方数据

中国糖尿病杂志中國糖尿病雜誌 중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2012年 10期 721-724 ,共4页

冯秋萍%李晓晶%苏燕%闫朝丽%高丽君%秦文斌%顾丽%张君%李彩萍%李爱珍

풍추평%리효정%소연%염조려%고려군%진문빈%고려%장군%리채평%리애진

糖尿病,2型%TCF7L2%单核苷酸多态性%基因型频率%单倍型糖尿病,2型%TCF7L2%單覈苷痠多態性%基因型頻率%單倍型
당뇨병,2형%TCF7L2%단핵감산다태성%기인형빈솔%단배형

目的研究内蒙古地区汉族人群中T2DM易感性与TCF7L2基因rs7903146T/C和rs7901695T/C位点单核苷酸多态性(SNPs)是否相关. 方法收集T2DM患者和正常体检人群的抗凝血,采用等位基因特异性PCR (AS-PCR)进行SNPs分析；运用SHEsis软件对T2DM组和正常对照(NC)组的TCF7L2基因的SNPs位点进行连锁不平衡和单倍型分析. 结果 rs7903146 T/C和rs7901695 T/C位点的基因型分布在T2DM及NC组间的分布差异无统计学意义(P＞0.05),但rs7903146T/C位点的T和C等位基因频率在两组间的分布差异有统计学意义(P＜0.05).rs7903146T/C和rs7901695 T/C位点连锁平衡(D’=0.060),rs7901695T-rs7903146T单倍型在T2DM组的频率明显高于NC组(P＜0.01,OR=1.803,95％CI:1.183～2.7487). 结论在内蒙古地区汉族人群,rs7903146位点C→T多态性可能与T2DM关联,携带突变等位基因T可增加罹患T2DM的风险,rs7901695位点C→T多态性与T2DM易感性无明显相关性,但rs7901695T-rs7903146T单倍型与T2DM发病风险相关.
목적 연구내몽고지구한족인군중T2DM역감성여TCF7L2기인rs7903146T/C화rs7901695T/C위점단핵감산다태성(SNPs)시부상관. 방법 수집T2DM환자화정상체검인군적항응혈,채용등위기인특이성PCR (AS-PCR)진행SNPs분석；운용SHEsis연건대T2DM조화정상대조(NC)조적TCF7L2기인적SNPs위점진행련쇄불평형화단배형분석. 결과 rs7903146 T/C화rs7901695 T/C위점적기인형분포재T2DM급NC조간적분포차이무통계학의의(P＞0.05),단rs7903146T/C위점적T화C등위기인빈솔재량조간적분포차이유통계학의의(P＜0.05).rs7903146T/C화rs7901695 T/C위점련쇄평형(D’=0.060),rs7901695T-rs7903146T단배형재T2DM조적빈솔명현고우NC조(P＜0.01,OR=1.803,95％CI:1.183～2.7487). 결론 재내몽고지구한족인군,rs7903146위점C→T다태성가능여T2DM관련,휴대돌변등위기인T가증가리환T2DM적풍험,rs7901695위점C→T다태성여T2DM역감성무명현상관성,단rs7901695T-rs7903146T단배형여T2DM발병풍험상관.