中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
6期
574-576
,共3页
胱抑素C%血清肌酐%急性肾损伤
胱抑素C%血清肌酐%急性腎損傷
광억소C%혈청기항%급성신손상
Cystatin C%Serum creatinine%Acute kidney injury
目的 探讨血清胱抑素C(Cystatin C)在危重患儿急性肾损伤(AKI)早期诊断中的价值.方法 收集重症监护病房中的危重患儿98例,根据是否发生AKI分为AKI组和非AKI组.每日采集血液标本,用免疫比浊法检测两组间Cystatin C浓度,用苦味酸法检测两组间血清肌酐(SCr)浓度.比较二者变化的相关性,及在AKI各期诊断的中位时间值的差异.结果 98例危重患儿中33例发生AKI,65例未发生AKI.AKI组患儿血清SCr[(209.21±100.53) μmol/L]和Cystatin C[(2.68±0.86) mg/L]较非AKI组患儿[(77.46±8.11) μμmol/L和(0.76±0.15) mg/L]显著升高,差异有统计学意义(t值分别为10.55、17.56,P均＜0.001)；且二者变化一致,呈正相关(r=0.874,P＜0.001).Cystatin C在AKI分期Ⅰ期、Ⅱ期和Ⅲ期的平均诊断时间分别为(3.0±2.5)、(5.0±3.0)、(9.0±4.0)d,较SCr((5.0±2.0)、(7.0±2.5)、(10.0±3.0)d)明显提前,差异有统计学意义(t值分别为4.39、2.29、3.16,P＜0.01或P＜0.05).结论 在AKI发生过程中,Cystatin C浓度升高较SCr早,因此Cystatin C可作为危重患儿AKI早期预测指标之一.
目的 探討血清胱抑素C(Cystatin C)在危重患兒急性腎損傷(AKI)早期診斷中的價值.方法 收集重癥鑑護病房中的危重患兒98例,根據是否髮生AKI分為AKI組和非AKI組.每日採集血液標本,用免疫比濁法檢測兩組間Cystatin C濃度,用苦味痠法檢測兩組間血清肌酐(SCr)濃度.比較二者變化的相關性,及在AKI各期診斷的中位時間值的差異.結果 98例危重患兒中33例髮生AKI,65例未髮生AKI.AKI組患兒血清SCr[(209.21±100.53) μmol/L]和Cystatin C[(2.68±0.86) mg/L]較非AKI組患兒[(77.46±8.11) μμmol/L和(0.76±0.15) mg/L]顯著升高,差異有統計學意義(t值分彆為10.55、17.56,P均＜0.001)；且二者變化一緻,呈正相關(r=0.874,P＜0.001).Cystatin C在AKI分期Ⅰ期、Ⅱ期和Ⅲ期的平均診斷時間分彆為(3.0±2.5)、(5.0±3.0)、(9.0±4.0)d,較SCr((5.0±2.0)、(7.0±2.5)、(10.0±3.0)d)明顯提前,差異有統計學意義(t值分彆為4.39、2.29、3.16,P＜0.01或P＜0.05).結論 在AKI髮生過程中,Cystatin C濃度升高較SCr早,因此Cystatin C可作為危重患兒AKI早期預測指標之一.
목적 탐토혈청광억소C(Cystatin C)재위중환인급성신손상(AKI)조기진단중적개치.방법 수집중증감호병방중적위중환인98례,근거시부발생AKI분위AKI조화비AKI조.매일채집혈액표본,용면역비탁법검측량조간Cystatin C농도,용고미산법검측량조간혈청기항(SCr)농도.비교이자변화적상관성,급재AKI각기진단적중위시간치적차이.결과 98례위중환인중33례발생AKI,65례미발생AKI.AKI조환인혈청SCr[(209.21±100.53) μmol/L]화Cystatin C[(2.68±0.86) mg/L]교비AKI조환인[(77.46±8.11) μμmol/L화(0.76±0.15) mg/L]현저승고,차이유통계학의의(t치분별위10.55、17.56,P균＜0.001)；차이자변화일치,정정상관(r=0.874,P＜0.001).Cystatin C재AKI분기Ⅰ기、Ⅱ기화Ⅲ기적평균진단시간분별위(3.0±2.5)、(5.0±3.0)、(9.0±4.0)d,교SCr((5.0±2.0)、(7.0±2.5)、(10.0±3.0)d)명현제전,차이유통계학의의(t치분별위4.39、2.29、3.16,P＜0.01혹P＜0.05).결론 재AKI발생과정중,Cystatin C농도승고교SCr조,인차Cystatin C가작위위중환인AKI조기예측지표지일.
Objective To investigate the early diagnostic value of serum Cystatin C in the diagnosis of acute kidney injury (AKI) in critically ill children.Methods Ninety-eight children of the severe case patients' rooms were divided into two groups:33 cases were AKI,65 cases were NAKI.Cystatin C and SCr in blood serum were detected by immunoturbidimetry and enzymic method every day.And compared serum Cystatin C,SCr concentrate and median diagnosis time between the two groups.Results Thirty-three cases in 98 cases of critically ill children occurred the AKI,65 patients without AKI.Comparing with the NAKI,the Cystatin C of AKI patients were significantly higher ((2.68 ±0.86) mg/L vs (0.76 ±0.15) mg/L) and SCr ((209.21 ± 100.53 ) μmol/L vs (77.46 ± 8.11) μmol/L),the differences were statistically significant (t =10.55,17.56,P ＜0.001) ; Cystatin C was in positive correlation with SCr (r =0.874,P ＜ 0.001) ; Median diagnosis time of AKI-Ⅰ,Ⅱ,and Ⅲ stage with Cystatin C were (3.0 ± 2.5) d,(5.0 ± 3.0) d and (9.0 ± 4.0) d,respectively,which was earlier than that of SCr ((5.0 ± 2.0) d,(7.0 ± 2.5) d and (10.0 ± 3.0) d,respectively; t =4.39,2.29,3.16,respectively ;P ＜ 0.01 or P ＜ 0.05).Conclusion In the process of AKI,the level of serum Cystatin C elevated significantly earlier than SCr,so it could as be one of the early dynamic criteria in the critically ill children.
