CAJ | 학술논문

目的：研究胸膜热烧灼联合胸腔镜辅助下局部肿瘤切除治疗肺癌恶性胸腔积液的临床效果。方法选择2010年6月至2011年6月本院肿瘤科行肺癌恶性胸腔积液手术治疗的37例患者作为试验组，选取同期在本院选择保守治疗的20例肺癌恶性胸腔积液患者作为对照组，对比分析两组患者的治疗效果。结果试验组治疗有效率为83.78%，明显高于对照组（45.0%），经过统计学检验两组有效率之间差异具有显著性（P＜0.05）；在治疗组中癌胚抗原（CEA）、糖类抗原125（CA-125）、细胞角蛋白19片段（CYFRA21-1）、神经元特异性烯醇化酶（NSE）的水平均明显降低，试验组与对照组中所检查指标治疗后与治疗前相比差异均具有显著性（P＜0.05）。治疗后两组CEA、CA-125、CYFRA21-1、NSE水平之间差异具有显著性（P＜0.05）；所有患者随访至2013年6月，结局均死亡。试验组中位生存时间为22.5个月，对照组中位生存时间为11.5个月。结论胸膜热烧灼联合胸腔镜辅助下局部肿瘤切除治疗肺癌恶性胸腔积液的效果明显，可以延长患者的生存时间。
목적：연구흉막열소작연합흉강경보조하국부종류절제치료폐암악성흉강적액적림상효과。방법선택2010년6월지2011년6월본원종류과행폐암악성흉강적액수술치료적37례환자작위시험조，선취동기재본원선택보수치료적20례폐암악성흉강적액환자작위대조조，대비분석량조환자적치료효과。결과시험조치료유효솔위83.78%，명현고우대조조（45.0%），경과통계학검험량조유효솔지간차이구유현저성（P＜0.05）；재치료조중암배항원（CEA）、당류항원125（CA-125）、세포각단백19편단（CYFRA21-1）、신경원특이성희순화매（NSE）적수평균명현강저，시험조여대조조중소검사지표치료후여치료전상비차이균구유현저성（P＜0.05）。치료후량조CEA、CA-125、CYFRA21-1、NSE수평지간차이구유현저성（P＜0.05）；소유환자수방지2013년6월，결국균사망。시험조중위생존시간위22.5개월，대조조중위생존시간위11.5개월。결론흉막열소작연합흉강경보조하국부종류절제치료폐암악성흉강적액적효과명현，가이연장환자적생존시간。
Objective To study the pleura joint local tumor resection under thoracoscope assisted heat burning clinical effect for the treatment of lung cancer with malignant pleural effusion. Methods Our hospital oncology in June 2010 to June 2011 line 37 cases of surgical operation in treating malignant pleural effusion of lung cancer patients as experimental group, at the same time selection in our hospital treatment but choose conservative treatment of 20 patients with lung cancer patients with malignant pleural effusion as control group, compared two groups of treatment effect. Results The treatment group effective rate was 83.78%, signiifcantly higher than that of control group effectiveness 45.0%, after a statistical test is the difference between the two groups of efifcient statistically signiifcant (P <0.05);After treatment of CEA, CA-125, CYFRA21-1, NSE levels were signiifcantly lower, check index in the experimental group after treatment compared with before treatment differences statistically significant (P<0.05), check indexes in the control group after treatment compared with before treatment differences statistically signiifcant (P<0.05). After treatment between two groups of CEA, CA-125, CYFRA21-1, NSE level differences statistically signiifcant (P<0.05);All patients followed up to June 2013, ending in death. The test median survival time was 22.5 months, control group median survival time was 11.5 months. Conclusion Pleural hot burning joint local tumor excision in the treatment of lung cancer with malignant pleural effusion under thoracoscope assisted effect signiifcantly, can prolong the survival time of patients.