中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
3期
263-266
,共4页
郑和昕%江缨%黄虹%袁放%吴天凤
鄭和昕%江纓%黃虹%袁放%吳天鳳
정화흔%강영%황홍%원방%오천봉
糖尿病,2型%骨质疏松%利钠肽,脑
糖尿病,2型%骨質疏鬆%利鈉肽,腦
당뇨병,2형%골질소송%리납태,뇌
Diabetes mellitus,type 2%Osteoporosis%Natriuretic peptide,brain
目的 评价老年男性2型糖尿病合并原发性骨质疏松症患者血浆脑钠肽(BNP)水平.方法 将老年男性患者122例按骨密度分为3组,骨量正常组41例、骨量减少组40例、骨质疏松组41例,另设年龄匹配的体检健康者33例为对照组,以酶标法检测各组血浆BNP水平. 结果 (1)骨质疏松组和骨量减少组血浆BNP明显高于骨量正常组及对照组,分别为(1.95±0.49) pmol/L和(1.64±0.48) pmol/L比(1.32±0.38) pmol/L和(1.26±0.39) pmol/L(P＜0.01),骨质疏松组高于骨量减少组(t=3.539,P＜0.05),骨量正常组高于对照组(t=2.726,P＜0.05)；(2)BNP与L2-4(r=-0.366)及股骨颈的骨密度(r=-0.375)、体质指数(r=-0.288)、雌二醇(r=-0.352)呈负相关(均P＜0.05),与甲状旁腺素呈正相关(r=0.353,P＜0.05). 结论 老年男性2型糖尿病患者随着骨密度的下降,血浆脑钠肽水平升高,可能与甲状旁腺素代偿性升高及雌二醇水平下降有关.
目的 評價老年男性2型糖尿病閤併原髮性骨質疏鬆癥患者血漿腦鈉肽(BNP)水平.方法 將老年男性患者122例按骨密度分為3組,骨量正常組41例、骨量減少組40例、骨質疏鬆組41例,另設年齡匹配的體檢健康者33例為對照組,以酶標法檢測各組血漿BNP水平. 結果 (1)骨質疏鬆組和骨量減少組血漿BNP明顯高于骨量正常組及對照組,分彆為(1.95±0.49) pmol/L和(1.64±0.48) pmol/L比(1.32±0.38) pmol/L和(1.26±0.39) pmol/L(P＜0.01),骨質疏鬆組高于骨量減少組(t=3.539,P＜0.05),骨量正常組高于對照組(t=2.726,P＜0.05)；(2)BNP與L2-4(r=-0.366)及股骨頸的骨密度(r=-0.375)、體質指數(r=-0.288)、雌二醇(r=-0.352)呈負相關(均P＜0.05),與甲狀徬腺素呈正相關(r=0.353,P＜0.05). 結論 老年男性2型糖尿病患者隨著骨密度的下降,血漿腦鈉肽水平升高,可能與甲狀徬腺素代償性升高及雌二醇水平下降有關.
목적 평개노년남성2형당뇨병합병원발성골질소송증환자혈장뇌납태(BNP)수평.방법 장노년남성환자122례안골밀도분위3조,골량정상조41례、골량감소조40례、골질소송조41례,령설년령필배적체검건강자33례위대조조,이매표법검측각조혈장BNP수평. 결과 (1)골질소송조화골량감소조혈장BNP명현고우골량정상조급대조조,분별위(1.95±0.49) pmol/L화(1.64±0.48) pmol/L비(1.32±0.38) pmol/L화(1.26±0.39) pmol/L(P＜0.01),골질소송조고우골량감소조(t=3.539,P＜0.05),골량정상조고우대조조(t=2.726,P＜0.05)；(2)BNP여L2-4(r=-0.366)급고골경적골밀도(r=-0.375)、체질지수(r=-0.288)、자이순(r=-0.352)정부상관(균P＜0.05),여갑상방선소정정상관(r=0.353,P＜0.05). 결론 노년남성2형당뇨병환자수착골밀도적하강,혈장뇌납태수평승고,가능여갑상방선소대상성승고급자이순수평하강유관.
Objective To evaluate plasma natriuretic peptide brain (BNP) levels in elderly male patients with type 2 diabetes and primary osteoporosis.Methods A total of 122 elderly male patients with type 2 diabetes were divided into 3 groups according to bone mineral density(BMD):normal group (41 cases),osteopenia group (40 cases) and osteoporosis group (41 cases),and another 33 age matched healthy subjects as control group.Plasma BNP levels were determined by ELISA.Results Plasma BNP levels in osteoporosis group [(1.95 ± 0.49) pmol/L] and osteopenia group [(1.64±0.48) pmol/L] were significantly elevated compared with that in normal group [(1.32±0.38) pmol/L] and control group [(1.26±0.39) pmol/L] (all P＜0.01).There was a statistical difference between osteoporosis group and osteopenia group (t=3.539,P＜0.05),and also between normal group and control group (t=2.726,P＜0.05).Plasma BNP levels had negative correlation with BMD of 2na-4th lumbar vertebra (r=-0.366) and femoral neck (r=-0.375),body mass index (r=-0.288) and estrodiol (E2) (r=-0.352) (all P＜0.05); while had a positive correlation with parathyroid hormone (PTH) (r=0.353,P＜0.05).Conclusions With BMD declining,plasma BNP levels are elevated in elderly male type 2 diabetes,which may be related to the compensatory increase in PTH and the decrease in estradiol.
