CAJ | 학술논문

目的：检测寻常型银屑病皮损中血管紧张素II( AngII)及血管紧张素转化酶( ACE)的水平变化。方法：应用荧光定量聚合酶链反应( FQ-PCR)和免疫组化技术检测30例寻常型银屑病患者(进行期17例，静止期13例)皮损Ang II和ACE mRNA及蛋白质的表达。结果：银屑病患者皮损中Ang II和ACE mRNA及蛋白质的表达明显高于正常人对照组(P<0.001)，且进行期高于静止期(P<0.001)。结论： Ang II和ACE 在银屑病皮损中表达上调，推测可能与银屑病皮损中新血管的形成有关。
목적：검측심상형은설병피손중혈관긴장소II( AngII)급혈관긴장소전화매( ACE)적수평변화。방법：응용형광정량취합매련반응( FQ-PCR)화면역조화기술검측30례심상형은설병환자(진행기17례，정지기13례)피손Ang II화ACE mRNA급단백질적표체。결과：은설병환자피손중Ang II화ACE mRNA급단백질적표체명현고우정상인대조조(P<0.001)，차진행기고우정지기(P<0.001)。결론： Ang II화ACE 재은설병피손중표체상조，추측가능여은설병피손중신혈관적형성유관。
Objective: To detect the level of angiotensin II (Ang II) and angiotensin converting enzyme ( ACE) in patients with psoriasis vulgaris. Methods:The level of Ang II and ACE was detected by fluorescent quantitative polymerase chain reaction ( FQ-PCR) and immunohistochemistry technique in 30 patients with psoriasis vulgaris ( progressing stage in 17 cases and stable stage in 13) and 15 normal controls. Results:The level of Ang II and ACE protein was significantly higher in psoriatic lesions than in controls ( P<0.001) and in progressing stage higher than in stable stage ( P<0.001) . Conclusion:Over expression of Ang II and ACE in psoriatic lesions may be implicated in the neovascularization of psoriasis.