CAJ | 학술논문

目的：探讨七叶皂苷钠对大鼠视网膜缺血再灌注损伤过程中 SOD和MDA表达的影响。方法：采用前房加压法制备大鼠视网膜缺血再灌注损伤模型，将SD大鼠随机分为正常组、缺血再灌注模型组和七叶皂苷钠治疗组，各组于术后3天检测视网膜组织中SOD活性和MDA含量。结果：大鼠视网膜缺血再灌注损伤后，七叶皂苷钠治疗组与缺血再灌注模型组相比，SOD活性明显升高，MDA含量明显降低，差异有统计学意义。结论：七叶皂苷钠可抵抗视网膜缺血再灌注损伤后的氧化损伤，其作用机制可能与提高SOD活性和降低MDA含量有关。
목적：탐토칠협조감납대대서시망막결혈재관주손상과정중 SOD화MDA표체적영향。방법：채용전방가압법제비대서시망막결혈재관주손상모형，장SD대서수궤분위정상조、결혈재관주모형조화칠협조감납치료조，각조우술후3천검측시망막조직중SOD활성화MDA함량。결과：대서시망막결혈재관주손상후，칠협조감납치료조여결혈재관주모형조상비，SOD활성명현승고，MDA함량명현강저，차이유통계학의의。결론：칠협조감납가저항시망막결혈재관주손상후적양화손상，기작용궤제가능여제고SOD활성화강저MDA함량유관。
Objective:To investigate the effect of aescinate on the expression of SOD and MDA in rat retina after ischemia -reperfusion injury.Methods:Male adult rats were randomly divided into 3 groups:normal control group , ischemia-reperfusion model group , aesci-nate-treated group.The model of retinal ischemia -reperfusion injury was made by transient elevating of intraocular pressure .The SOD activity and MDA content of retinal tissue were tested on 3 day after operation .Results:The SOD activity of aescinate -treated group was higher than that of ischemia -reperfusion model group , the MDA content of aescinate -treated group was lower than that of ischemia -reperfusion model group .Conclusion:Aescinate against oxidative damage in rat retina after ischemia -reperfusion injury , and its mecha-nism may be related to increasing the activity of SOD and decreased the content of MDA .