河北医学
河北醫學
하북의학
HEBEI MEDICINE
2014年
3期
427-429
,共3页
魏明琴%宋建%董佑红%袁丽
魏明琴%宋建%董祐紅%袁麗
위명금%송건%동우홍%원려
非鳞癌局部晚期肺癌%三维适形放疗%培美曲塞
非鱗癌跼部晚期肺癌%三維適形放療%培美麯塞
비린암국부만기폐암%삼유괄형방료%배미곡새
Locally advanced non-squamous lung cancer%Three-dimensional conformal radiother-apy%Pemetrexed
目的：观察三维适形放疗联合培美曲塞治疗非鳞癌局部晚期肺癌的近期疗效及毒性反应。方法：将2009年10月至2012年6月期间我院收治的非鳞癌局部晚期肺癌患者98例，将其随机分为观察组49例和对照组49例，观察组患者给予三维适形放疗联合培美曲塞进行治疗，对照组患者仅给予三维适形放疗，观察两组患者治疗的临床疗效及两组患者治疗后毒性反应的发生率。结果：两组患者经治疗后均取得一定的临床效果，观察组患者的有效率为63．3％明显高于对照组的32．7％，差异具有统计学意义（P＜0．05）；观察组患者毒性反应的发生率与对照组相比无显著差异（P＞0．05）。结论：三维适形放疗治疗非鳞癌局部晚期肺癌时应用培美曲塞能够显著提高患者的临床疗效，且用药后的毒性反应发生率没有增加，值得在临床普遍推广与应用。
目的：觀察三維適形放療聯閤培美麯塞治療非鱗癌跼部晚期肺癌的近期療效及毒性反應。方法：將2009年10月至2012年6月期間我院收治的非鱗癌跼部晚期肺癌患者98例，將其隨機分為觀察組49例和對照組49例，觀察組患者給予三維適形放療聯閤培美麯塞進行治療，對照組患者僅給予三維適形放療，觀察兩組患者治療的臨床療效及兩組患者治療後毒性反應的髮生率。結果：兩組患者經治療後均取得一定的臨床效果，觀察組患者的有效率為63．3％明顯高于對照組的32．7％，差異具有統計學意義（P＜0．05）；觀察組患者毒性反應的髮生率與對照組相比無顯著差異（P＞0．05）。結論：三維適形放療治療非鱗癌跼部晚期肺癌時應用培美麯塞能夠顯著提高患者的臨床療效，且用藥後的毒性反應髮生率沒有增加，值得在臨床普遍推廣與應用。
목적：관찰삼유괄형방료연합배미곡새치료비린암국부만기폐암적근기료효급독성반응。방법：장2009년10월지2012년6월기간아원수치적비린암국부만기폐암환자98례，장기수궤분위관찰조49례화대조조49례，관찰조환자급여삼유괄형방료연합배미곡새진행치료，대조조환자부급여삼유괄형방료，관찰량조환자치료적림상료효급량조환자치료후독성반응적발생솔。결과：량조환자경치료후균취득일정적림상효과，관찰조환자적유효솔위63．3％명현고우대조조적32．7％，차이구유통계학의의（P＜0．05）；관찰조환자독성반응적발생솔여대조조상비무현저차이（P＞0．05）。결론：삼유괄형방료치료비린암국부만기폐암시응용배미곡새능구현저제고환자적림상료효，차용약후적독성반응발생솔몰유증가，치득재림상보편추엄여응용。
Objective:To observe the efficacy and toxicity of the three-dimensional conformal radiother-apy combined with pemetrexed in the treatment of locally advanced non-squamous lung cancer .Method:98 patients with non-squamous locally advanced lung cancer were selected from October 2009 to June 2012 .The patients were randomly divided into observation group and control group , and each group with 49 cases.The observation group was treated with three-dimensional conformal radiotherapy combined with pemetrexed , while the control group was only treated with three-dimensional conformal radiotherapy .The clinical efficacy and the incidence of toxicity of the two groups were observed after treatment .Result: After treatment , the patients of the two groups had certain clinical affect .The effective rate of observation group was 63.3%higher than 32.7%of the control group, the difference was statistically significant (P<0.05);the incidence of tox-icity had no difference between the two groups , the difference was not statistically significant (P>0.05). Conclusion:The three-dimensional conformal radiation therapy for locally advanced non -squamous lung cancer combined with pemetrexed can significantly improve the clinical efficacy , and the incidence of toxicity did not increase after treatment , it is worth to be general promoted and applied in clinical .
