中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2013年
2期
120-123
,共4页
分泌型乳腺癌%临床病理特点
分泌型乳腺癌%臨床病理特點
분비형유선암%림상병리특점
Secretory breast cancer%Clinicopathological features
目的 乳腺分泌型癌是一种特殊类型乳腺癌,目前研究较少,多为个案报道,本研究旨在探讨分泌型乳腺癌的临床病理及预后特点.方法 回顾性分析1986年1月至2012年3月天津肿瘤医院收治的经病理确诊为分泌型乳腺癌39例的临床资料,中位随访时间73(2 ～221)个月,观察其临床病理特点及生存状况.结果 本组男2例,女37例；中位年龄52(11 ～75)岁；临床表现以乳房肿块为主,30例(76.9％)肿瘤为T2期(2 cm＜T≤5 cm),TNM分期29例(74.4％)Ⅱ期,24例(61.5％)无淋巴结转移；雌激素受体(estrogen receptor,ER)阳性表达17例(54.8％),孕激素受体(progesterone receptor,PR)阳性表达11例(37.9％),三阴性乳腺癌9例(42.9％)；随访2例(5.1％)患者死亡,2例20岁以下青少年患者未发现复发转移.结论 分泌型乳腺癌可见于任何年龄,男女均可发病,肿瘤以早期为主,激素受体阳性表达率低,三阴性乳腺癌多见,总体预后较好,但有远处转移风险,应长期随访观察,青少年患者预后优于成人.
目的 乳腺分泌型癌是一種特殊類型乳腺癌,目前研究較少,多為箇案報道,本研究旨在探討分泌型乳腺癌的臨床病理及預後特點.方法 迴顧性分析1986年1月至2012年3月天津腫瘤醫院收治的經病理確診為分泌型乳腺癌39例的臨床資料,中位隨訪時間73(2 ～221)箇月,觀察其臨床病理特點及生存狀況.結果 本組男2例,女37例；中位年齡52(11 ～75)歲；臨床錶現以乳房腫塊為主,30例(76.9％)腫瘤為T2期(2 cm＜T≤5 cm),TNM分期29例(74.4％)Ⅱ期,24例(61.5％)無淋巴結轉移；雌激素受體(estrogen receptor,ER)暘性錶達17例(54.8％),孕激素受體(progesterone receptor,PR)暘性錶達11例(37.9％),三陰性乳腺癌9例(42.9％)；隨訪2例(5.1％)患者死亡,2例20歲以下青少年患者未髮現複髮轉移.結論 分泌型乳腺癌可見于任何年齡,男女均可髮病,腫瘤以早期為主,激素受體暘性錶達率低,三陰性乳腺癌多見,總體預後較好,但有遠處轉移風險,應長期隨訪觀察,青少年患者預後優于成人.
목적 유선분비형암시일충특수류형유선암,목전연구교소,다위개안보도,본연구지재탐토분비형유선암적림상병리급예후특점.방법 회고성분석1986년1월지2012년3월천진종류의원수치적경병리학진위분비형유선암39례적림상자료,중위수방시간73(2 ～221)개월,관찰기림상병리특점급생존상황.결과 본조남2례,녀37례；중위년령52(11 ～75)세；림상표현이유방종괴위주,30례(76.9％)종류위T2기(2 cm＜T≤5 cm),TNM분기29례(74.4％)Ⅱ기,24례(61.5％)무림파결전이；자격소수체(estrogen receptor,ER)양성표체17례(54.8％),잉격소수체(progesterone receptor,PR)양성표체11례(37.9％),삼음성유선암9례(42.9％)；수방2례(5.1％)환자사망,2례20세이하청소년환자미발현복발전이.결론 분비형유선암가견우임하년령,남녀균가발병,종류이조기위주,격소수체양성표체솔저,삼음성유선암다견,총체예후교호,단유원처전이풍험,응장기수방관찰,청소년환자예후우우성인.
Objective Secretory breast cancer is a rare and specific subtype of breast carcinoma,and most reports on it are case report.This study is to explore the clinicopathological and prognosis characteristics of secretory breast cancer in Chinese.Methods The clinicopathological data of 39 patients of secretory breast cancer diagnosed from Jan.1986 to Mar.2012 at Tianjin Medical University Cancer Hospital were retrospectively analyzed.The postoperative follow-up was 2 to 221 months,with a median follow-up of 73 months.The clinicopathological features and survival condition were observed.Results There were 2 male and 37 female patients,ranging from 11 to 75 years old,with the median age of 52 years old.The main clinical manifestation of secretory breast cancer was breast mass.30 patients(76.9％)were in T2 breast cancer(2 cm ＜ T ≤5 cm),29 patients (74.4％)were in clinical stage Ⅱ according to TNM stage,and 24 patients (61.5％)had no lymph node metastasis.17 patients(54.8％)had positive expression of estrogen receptor(ER),11 patients(37.9％)had positive expression of progesterone receptor(PR),and 9 patients (42.9％) were triple negative breast cancer.During the follow-up,2 patients(5.1％)died from the disease,and 2 patients under than 20 had no recurrence or metastasis.Conclusions Secretory breast cancer occurs in both sexes with a wide age range,mostly in an early clinical stage.The positive expression rate of hormone receptor is low.The proportion of triple negative breast cancer is high.The overall prognosis of patients with secretory breast cancer is good.Because of the risk of metastasis,patients should be followed up for a long time.It seems that juvenile patients have a better prognosis.
