医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2013年
24期
95-95
,共1页
战晓慧%王占聚%刘永%徐晓燕%汪明玉
戰曉慧%王佔聚%劉永%徐曉燕%汪明玉
전효혜%왕점취%류영%서효연%왕명옥
热休克蛋白27%多发性骨髓瘤%耐药
熱休剋蛋白27%多髮性骨髓瘤%耐藥
열휴극단백27%다발성골수류%내약
HSP27%Myeloma%Drugresistant
目的：研究热休克蛋白27（HSP27）在多发性骨髓瘤患者中的表达，探讨其在多发性骨髓瘤患者治疗和预后中的价值。方法采用逆转录聚合酶链反应法（RT-PCR）测定多发性骨髓瘤患者组（耐药组、非耐药组）和健康成人组（正常组）HSP27 mRNA表达水平。结果耐药组和非耐药组HSP27表达水平均显著高于正常组；非耐药组HSP27表达水平高于耐药组。结论热休克蛋白27可作为评估多发性骨髓瘤治疗和预后的指标。
目的：研究熱休剋蛋白27（HSP27）在多髮性骨髓瘤患者中的錶達，探討其在多髮性骨髓瘤患者治療和預後中的價值。方法採用逆轉錄聚閤酶鏈反應法（RT-PCR）測定多髮性骨髓瘤患者組（耐藥組、非耐藥組）和健康成人組（正常組）HSP27 mRNA錶達水平。結果耐藥組和非耐藥組HSP27錶達水平均顯著高于正常組；非耐藥組HSP27錶達水平高于耐藥組。結論熱休剋蛋白27可作為評估多髮性骨髓瘤治療和預後的指標。
목적：연구열휴극단백27（HSP27）재다발성골수류환자중적표체，탐토기재다발성골수류환자치료화예후중적개치。방법채용역전록취합매련반응법（RT-PCR）측정다발성골수류환자조（내약조、비내약조）화건강성인조（정상조）HSP27 mRNA표체수평。결과내약조화비내약조HSP27표체수평균현저고우정상조；비내약조HSP27표체수평고우내약조。결론열휴극단백27가작위평고다발성골수류치료화예후적지표。
Objective to investigate the expression of hot shock protein 27 in multiple myeloma and discover the value of hsp27 on the treatment and prognosis in multiple myeloma. Method:RT-PCR method was used to study mRNA expression levels of HSP27 in multiple myeloma (drugresistant and non- drugresistant ) and normal healthy people;conclusion:levels of HSP27 in multiple myeloma (drugresistant and non-drugresistant ) are much higher than in normal healthy people, in non-drugresistant are higher than in drugresistant. Results Drugresistant and non-drugresistant group HSP27 expression levels were significantly higher than the normal group;non-drugresistant group HSP27 expression levels higher than Drugresistant group. Conclusion heat shock protein 27 can be used as treatment for multiple myeloma and assess prognosis.
