CAJ | 학술논문

目的：研究兰州地区汉族人群Megsin 基因C-2093T多态性与IgA 肾病的关系。方法采集兰州地区汉族的IgA 肾病患者48例及体检正常的兰州地区汉族健康体检人群100例作为对照组的Megsin 基因C-2093T，应用聚合酶链反应(PCR)进行检测和分析。结果 IgA 肾病组与健康对照组的 Megsin基因C-2093T多态性检测结果显示，TT基因型、CT基因型、CC基因型和C型、T型等位基因型均没有显著性差异（P<0.01）。结论 Megsin基因C-2093T多态性与兰州汉族人群IgA 肾病的发病可能无关。
목적：연구란주지구한족인군Megsin 기인C-2093T다태성여IgA 신병적관계。방법채집란주지구한족적IgA 신병환자48례급체검정상적란주지구한족건강체검인군100례작위대조조적Megsin 기인C-2093T，응용취합매련반응(PCR)진행검측화분석。결과 IgA 신병조여건강대조조적 Megsin기인C-2093T다태성검측결과현시，TT기인형、CT기인형、CC기인형화C형、T형등위기인형균몰유현저성차이（P<0.01）。결론 Megsin기인C-2093T다태성여란주한족인군IgA 신병적발병가능무관。
Objective:To investigate Megsin gene C-2093T polymorphism with IgA nephropathy.in the Han population of Lanzou area. Methods: Using the polymorphism chain reaction (PCR), Megsin gene C-2093T polymorphism was analyzed in 48 patients with IgA group and100healthy group in the Han population of Lanzou area. Results:The Megsin gene C-2093T polymorphism TT 、CT、CC gene type and C、T al ele frequencies were no significant dif erences than in healthy group (P<0.01). Conclusion:It is suggested that Megsin gene C-2093T polymorphism may not mat er with the IgA nephropathy in the Han population of Lanzou area .