中华普外科手术学杂志(电子版)
中華普外科手術學雜誌(電子版)
중화보외과수술학잡지(전자판)
CHINESE JOURNAL OF OPERATIVE PROCEDURES OF GENERAL SURGERY(ELECTRONIC VERSION)
2014年
2期
164-167
,共4页
锚蛋白类%结直肠肿瘤%预后
錨蛋白類%結直腸腫瘤%預後
묘단백류%결직장종류%예후
Ankyrins%Colorectal neoplasms%Prognosis
目的:探讨癌性锚蛋白重复序列(gann ankyrin repeats, Gankyrin)在结直肠癌和正常黏膜组织的表达情况及与各临床病理因素之间的关系。方法通过免疫组织化学SP法对55例结直肠癌组织、30例癌旁黏膜组织检测Gankyrin蛋白的表达,检测所得的数据采用SPSS13.0统计软件包进行分析,各组资料的比较均采用卡方检验,以P<0.05表示差异具有统计学意义。结果 Gankyrin蛋白在结直肠癌组织中的阳性表达率为78.2%,在癌旁黏膜组织中的阳性表达率为23.3%,其癌组织的阳性表达率明显高于癌旁黏膜组织(χ2=24.109, P<0.01);Gankyrin蛋白在同一结直肠癌患者的癌组织阳性表达高于癌旁黏膜组织的阳性表达(χ2=6.722, P<0.05);在伴有淋巴结转移的组织中Gankyrin蛋白的阳性表达率明显高于无淋巴结转移的癌组织(χ2=6.139, P<0.05),在TNM分期中,(Ⅲ+Ⅳ)期的癌组织Gankyrin蛋白的阳性表达率明显高于(Ⅰ+Ⅱ)期阳性表达率(χ2=5.130, P<0.05);Gankyrin蛋白在结直肠癌的阳性表达与年龄、性别、有无浆膜浸润和肿瘤的分化程度无显著关系(P>0.05)。结论 Gankyrin蛋白在结直肠癌组织中呈阳性表达,可能与肿瘤的发生发展有密切关系,对判断预后的意义有待进一步研究。
目的:探討癌性錨蛋白重複序列(gann ankyrin repeats, Gankyrin)在結直腸癌和正常黏膜組織的錶達情況及與各臨床病理因素之間的關繫。方法通過免疫組織化學SP法對55例結直腸癌組織、30例癌徬黏膜組織檢測Gankyrin蛋白的錶達,檢測所得的數據採用SPSS13.0統計軟件包進行分析,各組資料的比較均採用卡方檢驗,以P<0.05錶示差異具有統計學意義。結果 Gankyrin蛋白在結直腸癌組織中的暘性錶達率為78.2%,在癌徬黏膜組織中的暘性錶達率為23.3%,其癌組織的暘性錶達率明顯高于癌徬黏膜組織(χ2=24.109, P<0.01);Gankyrin蛋白在同一結直腸癌患者的癌組織暘性錶達高于癌徬黏膜組織的暘性錶達(χ2=6.722, P<0.05);在伴有淋巴結轉移的組織中Gankyrin蛋白的暘性錶達率明顯高于無淋巴結轉移的癌組織(χ2=6.139, P<0.05),在TNM分期中,(Ⅲ+Ⅳ)期的癌組織Gankyrin蛋白的暘性錶達率明顯高于(Ⅰ+Ⅱ)期暘性錶達率(χ2=5.130, P<0.05);Gankyrin蛋白在結直腸癌的暘性錶達與年齡、性彆、有無漿膜浸潤和腫瘤的分化程度無顯著關繫(P>0.05)。結論 Gankyrin蛋白在結直腸癌組織中呈暘性錶達,可能與腫瘤的髮生髮展有密切關繫,對判斷預後的意義有待進一步研究。
목적:탐토암성묘단백중복서렬(gann ankyrin repeats, Gankyrin)재결직장암화정상점막조직적표체정황급여각림상병리인소지간적관계。방법통과면역조직화학SP법대55례결직장암조직、30례암방점막조직검측Gankyrin단백적표체,검측소득적수거채용SPSS13.0통계연건포진행분석,각조자료적비교균채용잡방검험,이P<0.05표시차이구유통계학의의。결과 Gankyrin단백재결직장암조직중적양성표체솔위78.2%,재암방점막조직중적양성표체솔위23.3%,기암조직적양성표체솔명현고우암방점막조직(χ2=24.109, P<0.01);Gankyrin단백재동일결직장암환자적암조직양성표체고우암방점막조직적양성표체(χ2=6.722, P<0.05);재반유림파결전이적조직중Gankyrin단백적양성표체솔명현고우무림파결전이적암조직(χ2=6.139, P<0.05),재TNM분기중,(Ⅲ+Ⅳ)기적암조직Gankyrin단백적양성표체솔명현고우(Ⅰ+Ⅱ)기양성표체솔(χ2=5.130, P<0.05);Gankyrin단백재결직장암적양성표체여년령、성별、유무장막침윤화종류적분화정도무현저관계(P>0.05)。결론 Gankyrin단백재결직장암조직중정양성표체,가능여종류적발생발전유밀절관계,대판단예후적의의유대진일보연구。
[Abstract ] Objective To study the expression of Gankyrin(Gann ankyrin repeats,ankyrin repeat sequence ) in colorectal cancer ( CRC ) tissues and to investigate its relationship with clinical pathological factors. MethodsImmunohistochemical SP method was employed to detect the expression of Gankyrin protein in 55 tissues of CRC and 30 tissues of mucosa adjacent to carcinoma .Data were analyzed by the chi-square test using SPSS 13.0 software.A P value <0.05 was considered statistically significant . Results The positive expression rate of Gankyrin protein was 78.2% and 23.3% in CRC tissues and in mucosa tissues adjacent to carcinoma respectively (χ2 =24.109, P<0.01).In identical patients with CRC, the expression of Gankyrin protein in cancerous tissue was significantly higher than that in mucosa tissues adjacent to carcinoma (χ2 =6.722, P<0.05).The expression of Gankyrin protein in CRC with lymph node metastasis was significantly higher than that in CRC without lymph node metastasis (χ2 =6.139, P<0.05). The expression of Gankyrin protein in CRC with TNM stage Ⅲ or Ⅳ was significantly higher than that in CRC with TNM stage ⅠorⅡ(χ2 =5.130, P<0.05).The expression of Gankyrin protein in CRC did not correlate with age, gender, serosal invasion or the differentiation of tumor (P>0.05). Conclusions Gankyrin overexpresses in CRC tissues , which might be potentially correlated with the occurrence and development of tumor.Further study should focus on the predictive value of Gankyrin for prognosis .