CAJ | 학술논문

目的：探讨血小板活化测定对行经皮冠状动脉介入治疗（PCI）术后患者的抗血小板治疗的指导价值。方法选取2012年10月至2013年5月本院行PCI术的160例急性心肌梗死患者，随机分为监测组和对照组，各80例。其中监测组患者在术后3天和术后1周连续2次测定血小板活化功能，并相应地调整抗血小板药物的治疗方案。结果监测组患者的严重出血（颅内出血）和急性支架内血栓形成等严重不良反应发生例数显著低于对照组患者。结论 PCI术后连续监测血小板活化功能，并相应地调整抗血小板用药能够显著降低严重出血的风险，降低急性冠状动脉支架内血栓形成的概率，值得在临床上推广应用。
목적：탐토혈소판활화측정대행경피관상동맥개입치료（PCI）술후환자적항혈소판치료적지도개치。방법선취2012년10월지2013년5월본원행PCI술적160례급성심기경사환자，수궤분위감측조화대조조，각80례。기중감측조환자재술후3천화술후1주련속2차측정혈소판활화공능，병상응지조정항혈소판약물적치료방안。결과감측조환자적엄중출혈（로내출혈）화급성지가내혈전형성등엄중불량반응발생례수현저저우대조조환자。결론 PCI술후련속감측혈소판활화공능，병상응지조정항혈소판용약능구현저강저엄중출혈적풍험，강저급성관상동맥지가내혈전형성적개솔，치득재림상상추엄응용。
Objective To study the guiding value of the determination of platelet activation function for antiplatelet therapy in patients after PCI. Methods 160 inpatients with acute myocardial infarction from 2012 October to 2013 May those who underwent percutaneous coronary intervention therapy successfully were randomly divided into monitoring group and control group with 80 cases in each. The patients of monitoring group were measured the platelet activation function on the 3 day and 1 weeks after surgery, and were adjusted the treatment plan of antiplatelet drugs. Results The severe hemorrhage (ICH) and acute stent thrombosis and other serious adverse reactions occurred in the monitoring group of patients were significantly lower than those in the control group. Conclusion Monitoring the platelet activation after PCI, and adjusting the antiplatelet drugs can signiifcantly reduce the risk of serious bleeding and thrombosis in acute coronary stent. It is worthy to be popularized in clinical.