CAJ | 학술논문

右美托咪定是一高选择性α2受体激动剂，具有镇静、镇痛、抗焦虑和抑制交感活性等作用，现作为一种崭新的麻醉辅助药应用于手术和ICU镇静。近期诸多动物试验研究发现，右美托咪定具有神经保护作用，如调节脑血流与脑氧供，这可能与抑制中枢的交感活性，降低心率、增加氧供、降低氧耗有关。此外，其通过与α2A亚型受体结合产生的神经保护作用一方面可能与降低谷氨酸对神经元细胞的兴奋性毒性有关，另一方面通过抑制儿茶酚胺释放，从而改善缺血区域的血流灌注，并在调节神经元细胞凋亡等方面产生保护作用。同时，右美托咪定可能参与了调节其它细胞功能，如减少炎性因子的释放等。总而言之，其神经保护作用的确切机制尚不十分明确，并大多限于动物试验，故将来需在临床研究中深入到分子及基因水平。
우미탁미정시일고선택성α2수체격동제，구유진정、진통、항초필화억제교감활성등작용，현작위일충참신적마취보조약응용우수술화ICU진정。근기제다동물시험연구발현，우미탁미정구유신경보호작용，여조절뇌혈류여뇌양공，저가능여억제중추적교감활성，강저심솔、증가양공、강저양모유관。차외，기통과여α2A아형수체결합산생적신경보호작용일방면가능여강저곡안산대신경원세포적흥강성독성유관，령일방면통과억제인다분알석방，종이개선결혈구역적혈류관주，병재조절신경원세포조망등방면산생보호작용。동시，우미탁미정가능삼여료조절기타세포공능，여감소염성인자적석방등。총이언지，기신경보호작용적학절궤제상불십분명학，병대다한우동물시험，고장래수재림상연구중심입도분자급기인수평。
Dexmedetomidine is a highly selective α2 adrenoreceptor agonist,which exhibits a wide range of effects,including sedation,analgesia,antianxiety and sympatholytic properties.As an anaesthetic adjuvant,it is widely used in operative processes and ICU sedation.Recently,in a good deal of animal experiments,dexmedetomidine has been demonstrated that it has neuroprotective effects,such as the function of adjusting cerebral blood flow and cerebral oxygen supply.It may be relat-ed to attenuating sympathetic activation,dropping heart rate,increasing oxygen supply while decreasing the consumption,so that it can keep the myocardial oxygen balance complications.In addition,by the binding of dexmedetomidine andα2 A sub-type receptor,the neuroprotective effects might be related with receding the excitatory toxicity of glutamate.On the other hand,it can attenuate catecholamine release,improve the blood perfusion of ischemia area,and adjust the apoptosis of neu-ron cells,etc.In the mean time,dexmedetomidine may be involved in the other adjusting of cell function.In conclusion,the exact mechanisms of its neuroprotective effects are still unclear,and are confined to the animal experiments.Future clinical research need to aim at investigating the molecular and genetic mechanisms of its cardioprotective effects.