CAJ | 학술논문

目的：评价益生菌治疗成人特应性皮炎( AD)的疗效。方法：40例AD患者随机分为A组和B组，A组给予抗组胺药、0.05％地奈德乳膏及益生菌制剂，B组仅给予抗组胺药和0.05％地奈德乳膏，两组均治疗12周。20名健康者作为对照。治疗前、后及治疗后2个月用SCORAD和VAS法进行病情评分，并用PCR荧光定量法检测受试者粪便中的细菌水平。结果：治疗结束时，A组、B组评分较治疗前均显著降低(P<0.01)；停药2个月时，A组评分仍低于治疗前(P<0.01)，而此时B组评分与治疗前相比无统计学差异。治疗前A、B组双歧杆菌及乳酸杆菌的数量明显低于健康对照组(P<0.01)。治疗结束及停药2个月时，A组两种杆菌较治疗前均显著增加(P<0.01)，B组两种杆菌较治疗前均无显著差异。结论：益生菌可通过增加肠道双歧杆菌及乳酸杆菌菌群而改善病情并延缓复发。
목적：평개익생균치료성인특응성피염( AD)적료효。방법：40례AD환자수궤분위A조화B조，A조급여항조알약、0.05％지내덕유고급익생균제제，B조부급여항조알약화0.05％지내덕유고，량조균치료12주。20명건강자작위대조。치료전、후급치료후2개월용SCORAD화VAS법진행병정평분，병용PCR형광정량법검측수시자분편중적세균수평。결과：치료결속시，A조、B조평분교치료전균현저강저(P<0.01)；정약2개월시，A조평분잉저우치료전(P<0.01)，이차시B조평분여치료전상비무통계학차이。치료전A、B조쌍기간균급유산간균적수량명현저우건강대조조(P<0.01)。치료결속급정약2개월시，A조량충간균교치료전균현저증가(P<0.01)，B조량충간균교치료전균무현저차이。결론：익생균가통과증가장도쌍기간균급유산간균균군이개선병정병연완복발。
Objective: To evaluate clinical efficacy of probiotics for the treatment of adult AD patients. Methods:Forty patients were enrolled in this study and divided into two groups:the patients in the probiotics group were treated with antihistamine,topical steroid and probiotics. The patients in the non-probiotics group were treated with antihistamine and topical steroid only. The course of the treatment was 12 weeks. Twenty healthy people were used as control. The disease severity was assessed by SCORAD and VAS score at base-line,week 12 and month 2 after stopping the treatment. The change in fecal microbiota was detected by PCR. Results:The SCORAD and VAS scores were significantly reduced in the two groups ( P<0.01) after the treat-ment,compared with those before the treatment. At month 2 after stopping the treatment, the SCORAD and VAS scores continued to be lower than those at baseline in the probiotics group ( P<0.01),but not in the non-probiotics group. Before the treatment, the amount of Bifidobacterium and Lactobacilli in stool of the two groups was higher than that in the healthy control ( P<0.01) . At end of the treatment and month 2 after stop-ping the treatment, the amount of Bifidobacterium and Lactobacilli was significantly increased (P<0.01) in probiotics group,rather than in non-probiotics group. Conclusion:Probiotics can improve the clinical status of the disease through increasing the amount of Bifidobacterium and Lactobacilli,and prolong relapse of AD.