CAJ | 학술논문

目的：探究二甲双胍联合阿托伐他汀治疗2型糖尿病动脉粥样硬化患者的效果。方法120例2型糖尿病合并动脉粥样硬化患者分为对照组和观察组，对照组糖尿病患者给予二甲双胍、诺和灵30R降糖，观察组患者在对照组药物治疗的基础上给予二甲双胍和阿托伐他汀联合用药，比较治疗前后两组患者血脂变化及颈动脉粥样硬化内膜中膜厚度变化情况。结果观察组MT由治疗前（1.63±0.15）mm缩小为（1.39±0.22）mm，前后比较差异显著（P<0.05），而对照组治疗前后MT差异不明显（P>0.05）。观察组患者治疗后的TC、TG、LDL指标与治疗前相比均有显著降低，差异有统计学意义（P<0.05）；而对照组除LDL指标治疗前后有显著差异（P<0.05）外，其他几项比较均无显著差异（P>0.05）。结论二甲双胍联合阿托伐他汀治疗2型糖尿病动脉粥样硬化比使用二甲双胍和其他将糖类药物在控制血糖缓解动脉粥样硬化方面更具有优势。
목적：탐구이갑쌍고연합아탁벌타정치료2형당뇨병동맥죽양경화환자적효과。방법120례2형당뇨병합병동맥죽양경화환자분위대조조화관찰조，대조조당뇨병환자급여이갑쌍고、낙화령30R강당，관찰조환자재대조조약물치료적기출상급여이갑쌍고화아탁벌타정연합용약，비교치료전후량조환자혈지변화급경동맥죽양경화내막중막후도변화정황。결과관찰조MT유치료전（1.63±0.15）mm축소위（1.39±0.22）mm，전후비교차이현저（P<0.05），이대조조치료전후MT차이불명현（P>0.05）。관찰조환자치료후적TC、TG、LDL지표여치료전상비균유현저강저，차이유통계학의의（P<0.05）；이대조조제LDL지표치료전후유현저차이（P<0.05）외，기타궤항비교균무현저차이（P>0.05）。결론이갑쌍고연합아탁벌타정치료2형당뇨병동맥죽양경화비사용이갑쌍고화기타장당류약물재공제혈당완해동맥죽양경화방면경구유우세。
Objective To explore metformin atorvastatin treatment Type 2 diabetes patients with atherosclerosis effect. Methods 120 patients with type 2 diabetes and atherosclerosis patients were divided into control group and observation group and control group were treated with metformin diabetic, hypoglycemic Novolin 30R, observe patients in the control group on the basis of drug treatment given metformin and A ADS atorvastatin combination therapy, compared two groups of patients before and after treatment changes in blood lipids and carotid atherosclerosis intima-media thickness changes. Results The MT by the pre-treatment (1.63 ± 0.15) mm reduced to (1.39 ± 0.22) mm, a signiifcant difference between before and after (P<0.05), while the control group before and after treatment MT signiifcant difference (P>0.05). The patients after treatment TC, TG, LDL indicators compared with before treatment were signiifcantly lower, the difference was statistically signiifcant (P<0.05);while the control group before and after treatment than LDL were signiifcantly different (P<0.05) outside , several other showed no signiifcant difference (P>0.05). Conclusion Metformin atorvastatin treatment Type 2 diabetes atherosclerosis than using metformin and other drugs in the control of blood glucose sugars will ease aspects of atherosclerosis has more advantages.