医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2013年
29期
64-65
,共2页
细菌纤维素膜%布洛芬%体外释放
細菌纖維素膜%佈洛芬%體外釋放
세균섬유소막%포락분%체외석방
Acterial cellulose membrane%Ibuprofen%In vitro release
目的：制备布洛芬--细菌纤维素载药膜，并考察布洛芬--细菌纤维素膜的体外释放特性。方法紫外分光光度法测定布洛芬原料药的含量；将布洛芬溶解于乙醇中，并用浸泡法载入细菌纤维素膜；利用紫外分光光度法，考察布洛芬--细菌纤维素膜的体外释放特性。结果布洛芬--细菌纤维素膜的体外释放曲线拟合，更加符合weibul 函数分布，有一定的缓释作用。结论布洛芬原料药用浸泡法可载入细菌纤维素膜，布洛芬--细菌纤维素膜有一定的缓释作用，有望开发为布洛芬的新型缓释药物载体材料。
目的：製備佈洛芬--細菌纖維素載藥膜，併攷察佈洛芬--細菌纖維素膜的體外釋放特性。方法紫外分光光度法測定佈洛芬原料藥的含量；將佈洛芬溶解于乙醇中，併用浸泡法載入細菌纖維素膜；利用紫外分光光度法，攷察佈洛芬--細菌纖維素膜的體外釋放特性。結果佈洛芬--細菌纖維素膜的體外釋放麯線擬閤，更加符閤weibul 函數分佈，有一定的緩釋作用。結論佈洛芬原料藥用浸泡法可載入細菌纖維素膜，佈洛芬--細菌纖維素膜有一定的緩釋作用，有望開髮為佈洛芬的新型緩釋藥物載體材料。
목적：제비포락분--세균섬유소재약막，병고찰포락분--세균섬유소막적체외석방특성。방법자외분광광도법측정포락분원료약적함량；장포락분용해우을순중，병용침포법재입세균섬유소막；이용자외분광광도법，고찰포락분--세균섬유소막적체외석방특성。결과포락분--세균섬유소막적체외석방곡선의합，경가부합weibul 함수분포，유일정적완석작용。결론포락분원료약용침포법가재입세균섬유소막，포락분--세균섬유소막유일정적완석작용，유망개발위포락분적신형완석약물재체재료。
Objective To prepare Ibuprofen-Bacterial cellulose and to investigate its in vitro release characteristics. Method Uv spectrophotometry method was used to determine the content of ibuprofen bulk pharmaceutical chemicals.Ibuprofen was dissolved in ethanol and soak into the bacterial cellulose membrane.Uv spectrophotometric method was used to investigate in vitro release characteristics of Ibuprofen-Bacterial. Results In vitro release curve was more fit ing in line with the weibul formula.Ibuprofen-Bacterial cellulose showed a slow-release ef ect. Conclusion Ibuprofen bulk pharmaceutical chemicals can be soaked into the bacterial cellulose membrane and has a slow-release ef ect.The bacterial cellulose membrane is expected to be developed into a new slow-release drug carrier material for ibuprofen.
