CAJ | 학술논문

目的：探讨机体患新生隐球菌性脑膜炎与其抵抗力降低或免疫缺陷的关系。方法收集2009年1月~2012年11月住院的106例新生隐球菌性脑膜炎患者的临床资料，对患者的临床诊断，实验室及病原学检查等进行回顾分析。结果106例新生隐球菌感染患者中发现80例（占75.5%）患有慢性基础性疾病，其中患糖尿病者最多，有36例；乙型肝炎病毒感染31例，结核菌感染12例，系统特性红斑狼疮7例，AIDS 3例，丙型病毒性肝炎3例，单纯疱疹病毒感染3例,酒精性肝硬化1例，肝恶性肿瘤1例。结论新生隐球菌性脑膜炎患者发病前与机体免疫力低下或免疫缺陷有明显的关系,且以糖尿病为主，其次为乙型病毒性肝炎。
목적：탐토궤체환신생은구균성뇌막염여기저항력강저혹면역결함적관계。방법수집2009년1월~2012년11월주원적106례신생은구균성뇌막염환자적림상자료，대환자적림상진단，실험실급병원학검사등진행회고분석。결과106례신생은구균감염환자중발현80례（점75.5%）환유만성기출성질병，기중환당뇨병자최다，유36례；을형간염병독감염31례，결핵균감염12례，계통특성홍반랑창7례，AIDS 3례，병형병독성간염3례，단순포진병독감염3례,주정성간경화1례，간악성종류1례。결론신생은구균성뇌막염환자발병전여궤체면역력저하혹면역결함유명현적관계,차이당뇨병위주，기차위을형병독성간염。
Objective:To explore the relationship between those who suf ered from cryptococcus neoformans meningitis (CNM) and the ones with lower resistance or immunodeficiency. Method:By analysing 106 clinical datas col ecting from those who were hospitalized with CNM from January 2009 to November 2012 according to the clinical diagnosis,laboratory diagnosis and etiological examination. Results: 80 patients (75.5%) were found suf ering from chronic basis diseases especial y Diabetes mel itus(36 patients) in the ones(106 patients ) infected with CNM . Secondly , 31 patients were infected with hepatitis B ,12 were infected with tubercle bacil us , 7were infected wirh SLE , 3 were infected AIDS , 3 were infected with HSV, 3 were infected with hepatitis C , one person got alcoholic cirrhosis , one person got hepatic cancer. Conclusions: Correlation was found obviously between the ones with lower resistance or immunodeficiency especial y Diabetes mel itus,secondly is hepatitis B, and at acking from cryptococcus neoformans meningitis.