中国医疗设备
中國醫療設備
중국의료설비
CHINA MEDICAL EQUIPMENT
2012年
11期
21-25
,共5页
高天翼%李瑞%许晔琼%聂珍琳%顾玲%陈丽萍%宋国齐%王书奎
高天翼%李瑞%許曄瓊%聶珍琳%顧玲%陳麗萍%宋國齊%王書奎
고천익%리서%허엽경%섭진림%고령%진려평%송국제%왕서규
结直肠癌%多态性%OGG1
結直腸癌%多態性%OGG1
결직장암%다태성%OGG1
目的 对OGG1 Ser326Cys多态性与结直肠癌的关系做出更为准确的结论.方法 通过对12篇文章采用meta分析评估OGG1 Ser326Cys多态性与结直肠癌发病率的关系.用合并比值比(OR)描述显性模型(Cys/Cys vs Ser/Ser; Ser/Cys vs Ser/Ser),主导模型(Ser/Cys+ Cys/Cys vs Ser/Ser),隐性模型(Cys/Cys vs Ser/Cys+ Ser/Ser).结果 Cys/Cys vs Ser/Ser(OR=1.19,95％可信区间(CI)=0.92～1.53)、Ser/Cys vs Ser/Ser(OR=1.04,95％CI=0.95～1.13)、Ser/Cys+ Cys/Cys vs Ser/Ser(OR=1.06,95％CI=0.98～1.16)和Cys/Cys vs Ser/Cys+ Ser/Ser(OR=1.11,95％CI=0.90～1.38)无明显联系,此外,在分层分析中,所有基因型未见明显发病风险差异.结论 meta分析表明OGG1Ser326Cys多态性与结直肠癌总发病率无联系.
目的 對OGG1 Ser326Cys多態性與結直腸癌的關繫做齣更為準確的結論.方法 通過對12篇文章採用meta分析評估OGG1 Ser326Cys多態性與結直腸癌髮病率的關繫.用閤併比值比(OR)描述顯性模型(Cys/Cys vs Ser/Ser; Ser/Cys vs Ser/Ser),主導模型(Ser/Cys+ Cys/Cys vs Ser/Ser),隱性模型(Cys/Cys vs Ser/Cys+ Ser/Ser).結果 Cys/Cys vs Ser/Ser(OR=1.19,95％可信區間(CI)=0.92～1.53)、Ser/Cys vs Ser/Ser(OR=1.04,95％CI=0.95～1.13)、Ser/Cys+ Cys/Cys vs Ser/Ser(OR=1.06,95％CI=0.98～1.16)和Cys/Cys vs Ser/Cys+ Ser/Ser(OR=1.11,95％CI=0.90～1.38)無明顯聯繫,此外,在分層分析中,所有基因型未見明顯髮病風險差異.結論 meta分析錶明OGG1Ser326Cys多態性與結直腸癌總髮病率無聯繫.
목적 대OGG1 Ser326Cys다태성여결직장암적관계주출경위준학적결론.방법 통과대12편문장채용meta분석평고OGG1 Ser326Cys다태성여결직장암발병솔적관계.용합병비치비(OR)묘술현성모형(Cys/Cys vs Ser/Ser; Ser/Cys vs Ser/Ser),주도모형(Ser/Cys+ Cys/Cys vs Ser/Ser),은성모형(Cys/Cys vs Ser/Cys+ Ser/Ser).결과 Cys/Cys vs Ser/Ser(OR=1.19,95％가신구간(CI)=0.92～1.53)、Ser/Cys vs Ser/Ser(OR=1.04,95％CI=0.95～1.13)、Ser/Cys+ Cys/Cys vs Ser/Ser(OR=1.06,95％CI=0.98～1.16)화Cys/Cys vs Ser/Cys+ Ser/Ser(OR=1.11,95％CI=0.90～1.38)무명현련계,차외,재분층분석중,소유기인형미견명현발병풍험차이.결론 meta분석표명OGG1Ser326Cys다태성여결직장암총발병솔무련계.
