CAJ | 학술논문

目的：探讨了肾病综合症患儿治疗前后血浆Leptin和血清IL-10，INFα水平的变化及临床意义。方法应用放射免疫分析法和酶联法对30例肾病综合症患儿进行治疗前后血浆Leptin和血清IL-10，INFα水平检测，并与30名正常健康儿作比较。结果肾病综合症患儿在治疗前血浆Leptin和血清IL-10， INFα水平均非常显著地高于正常健康儿组（p＜0.01）经中西医结合治疗3个月后与正常健康儿比较仍有显著性差异（p＜0.05）。血浆Leptin和血清IL-10， INFα水平呈显著正相关（γ=0.5988，γ=0.6012，p＜0.01）。结论检测肾病综合症患儿治疗前后血浆Leptin和血清IL-10，INFα水平的变化对了解病情和观察预后均具有十分重要的临床价值。
목적：탐토료신병종합증환인치료전후혈장Leptin화혈청IL-10，INFα수평적변화급림상의의。방법응용방사면역분석법화매련법대30례신병종합증환인진행치료전후혈장Leptin화혈청IL-10，INFα수평검측，병여30명정상건강인작비교。결과신병종합증환인재치료전혈장Leptin화혈청IL-10， INFα수평균비상현저지고우정상건강인조（p＜0.01）경중서의결합치료3개월후여정상건강인비교잉유현저성차이（p＜0.05）。혈장Leptin화혈청IL-10， INFα수평정현저정상관（γ=0.5988，γ=0.6012，p＜0.01）。결론검측신병종합증환인치료전후혈장Leptin화혈청IL-10，INFα수평적변화대료해병정화관찰예후균구유십분중요적림상개치。
Objective To study the Clinical significance of changes of plasma Leptin and serum IL-10, INFα levels after treatment in patients with Children Nephrotic Syndrome (CNS). Methods Plasma Leptin and serum TNF-α (with RIA), Serum IL-10 (with ELISA) Levels were measured in 30 patients with CNS both before and after treatment as wel as in 30 healthy controls. Results Both before and after treatment, the levels of plasma Leptin and serum IL-10,TNF-αin patients with CNS were significantly higher than those in controls (P<0.01). After treatment for 3 months, the levels of Leptin, IL-10 and TNF-αwere significantly higher than before (P<0.05). Plasma leptin levels were positively correlated with IL-10, TNF-αlevels (r=0.598, 0.601; P<0.01). Conclusion Changes of plasma leptin and serum IL-10, TNF-αlevels after treatment might be of prognostic importance in patients with CNS.