CAJ | 학술논문

目的：探讨低压稳恒直流电场直接作用于正常家兔心脏对心脏电损伤的影响。方法家兔开胸后直接在心外膜上，于心尖处室间沟下段安放一对Pt电极，施与（0～6）V /cm稳恒直流电场，监测ECG和正电极处心外膜表面温度，光镜和电镜观察心肌组织学变化。结果17只家兔，场强＞3.5V /cm 出现各种快速室性心律失常。3.5V/cm和（4.0～4.5）V/cm两种电场作用后1h正电极处温度升高分别为（1.05±0.81）℃、（1.14±0.23）℃，二者无统计学差异（P>0.05）。3.5V/cm场强作用1h后心肌仅见变性和炎性细胞浸润，（4.0～4.5）V/cm场强作用后还可见凝固性坏死和异常收缩带。结论场强≤3.5 V/cm对心脏电损伤不明显。
목적：탐토저압은항직류전장직접작용우정상가토심장대심장전손상적영향。방법가토개흉후직접재심외막상，우심첨처실간구하단안방일대Pt전겁，시여（0～6）V /cm은항직류전장，감측ECG화정전겁처심외막표면온도，광경화전경관찰심기조직학변화。결과17지가토，장강＞3.5V /cm 출현각충쾌속실성심률실상。3.5V/cm화（4.0～4.5）V/cm량충전장작용후1h정전겁처온도승고분별위（1.05±0.81）℃、（1.14±0.23）℃，이자무통계학차이（P>0.05）。3.5V/cm장강작용1h후심기부견변성화염성세포침윤，（4.0～4.5）V/cm장강작용후환가견응고성배사화이상수축대。결론장강≤3.5 V/cm대심장전손상불명현。
Objective: To investigate the cardiac electrical injuries caused by the applied weak steady DC EFs in rabbits. Methods: A pair of Pt electrodes were paral el y placed on the cardiac apex epicardium at the two sides of the main branch of the left coronary artery in the rabbit hearts by thoracotomy without endotracheal intubation, fol owed by which a DC EFs range of 0 to 6.0V/cm was applied. The limb-lead ECGs and the epicardial temperature in the anelectrode were monitored, and the myocardial histologic structures were observed under the light microscope and the transmission electron microscope. Results: In 17 rabbits EFs of 0 to 3.5 V/cm failed to cause any ventricular arrhythmia. Electrical stimulation for 1h at 3.5 V/cm and 4.0 or 4.5 V/cm only increased the epicardial temperature in the anelectrode by(1.05±0.81)℃、(1.14±0.23)℃ respectively, but having no statistical significance(P>0.05). Additional y, after electrical stimulation for 1h at 3.5 V/cm there were only inflammatory cellinfiltrate and denaturation in the myocardium . Howerever, anomalism contraction bands and focal coagulation necrosis of myocardium were stil observed after electrical stimulation for 1h at 4.0 or 4.5 V/cm .Conclusion: The weak steady EFs(≤3.5V/cm) failed to cause the cardiac electrical injuries obviously .