中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
31期
77-78
,共2页
王家芳%肖承文%肖晓琴%丁乃琪
王傢芳%肖承文%肖曉琴%丁迺琪
왕가방%초승문%초효금%정내기
低剂量%三联标准疗法%幽门螺杆菌%消化性溃疡
低劑量%三聯標準療法%幽門螺桿菌%消化性潰瘍
저제량%삼련표준요법%유문라간균%소화성궤양
Low dose%Standard triple therapy%Helicobacter pylori%Peptic ulcer
目的:探讨低剂量三联标准疗法治疗消化性溃疡幽门螺旋杆菌(H.pylori,Hp)阳性患者的临床疗效,并观察其溃疡复发率Hp再感染率及不良反应。方法:选取符合标准的84例患者平均分成治疗组和对照组。对照组运用奥美拉唑20 mg,2次/d;羟氨苄青霉素500 mg,4次/d;甲硝唑400 mg,4次/d,均服用1周。治疗组奥美拉唑20 mg,1次/d;羟氨苄青霉素500 mg,2次/d,甲硝唑400 mg,2次/d,经1周治疗后,不再用其他任何抗溃疡药。1个月后复查胃镜及检测Hp,并观察患者的Hp根除率、溃疡愈合率;12个月后随访患者的复发率及再感染率。结果:治疗组根除率为95.23%(40/42)、溃疡愈合率为92.86%(39/42),对照组为90.48%(38/42)、88.09%(37/39),两组比较差异均无统计学意义(P>0.05);12个月后随访治疗组Hp根除者溃疡年复发率4.76%(2/42)、Hp再感染率7.14%(3/42),对照组为26.19%(11/42)、28.57%(12/42),两组比较差异均有统计学意义(P<0.05);治疗组不良反应发生率7.14%(3/42),对照组为11.90%(5/42),两组比较差异无统计学意义(P>0.05)。结论:低剂量三联标准疗法治疗Hp阳性消化性溃疡愈合率高, Hp根除率高,溃疡复发率及Hp再感染率低,是临床应用有价值的方案。
目的:探討低劑量三聯標準療法治療消化性潰瘍幽門螺鏇桿菌(H.pylori,Hp)暘性患者的臨床療效,併觀察其潰瘍複髮率Hp再感染率及不良反應。方法:選取符閤標準的84例患者平均分成治療組和對照組。對照組運用奧美拉唑20 mg,2次/d;羥氨芐青黴素500 mg,4次/d;甲硝唑400 mg,4次/d,均服用1週。治療組奧美拉唑20 mg,1次/d;羥氨芐青黴素500 mg,2次/d,甲硝唑400 mg,2次/d,經1週治療後,不再用其他任何抗潰瘍藥。1箇月後複查胃鏡及檢測Hp,併觀察患者的Hp根除率、潰瘍愈閤率;12箇月後隨訪患者的複髮率及再感染率。結果:治療組根除率為95.23%(40/42)、潰瘍愈閤率為92.86%(39/42),對照組為90.48%(38/42)、88.09%(37/39),兩組比較差異均無統計學意義(P>0.05);12箇月後隨訪治療組Hp根除者潰瘍年複髮率4.76%(2/42)、Hp再感染率7.14%(3/42),對照組為26.19%(11/42)、28.57%(12/42),兩組比較差異均有統計學意義(P<0.05);治療組不良反應髮生率7.14%(3/42),對照組為11.90%(5/42),兩組比較差異無統計學意義(P>0.05)。結論:低劑量三聯標準療法治療Hp暘性消化性潰瘍愈閤率高, Hp根除率高,潰瘍複髮率及Hp再感染率低,是臨床應用有價值的方案。
목적:탐토저제량삼련표준요법치료소화성궤양유문라선간균(H.pylori,Hp)양성환자적림상료효,병관찰기궤양복발솔Hp재감염솔급불량반응。방법:선취부합표준적84례환자평균분성치료조화대조조。대조조운용오미랍서20 mg,2차/d;간안변청매소500 mg,4차/d;갑초서400 mg,4차/d,균복용1주。치료조오미랍서20 mg,1차/d;간안변청매소500 mg,2차/d,갑초서400 mg,2차/d,경1주치료후,불재용기타임하항궤양약。1개월후복사위경급검측Hp,병관찰환자적Hp근제솔、궤양유합솔;12개월후수방환자적복발솔급재감염솔。결과:치료조근제솔위95.23%(40/42)、궤양유합솔위92.86%(39/42),대조조위90.48%(38/42)、88.09%(37/39),량조비교차이균무통계학의의(P>0.05);12개월후수방치료조Hp근제자궤양년복발솔4.76%(2/42)、Hp재감염솔7.14%(3/42),대조조위26.19%(11/42)、28.57%(12/42),량조비교차이균유통계학의의(P<0.05);치료조불량반응발생솔7.14%(3/42),대조조위11.90%(5/42),량조비교차이무통계학의의(P>0.05)。결론:저제량삼련표준요법치료Hp양성소화성궤양유합솔고, Hp근제솔고,궤양복발솔급Hp재감염솔저,시림상응용유개치적방안。
Objective:To investigate the clinical curative effect of combination therapy with low dose in the treatment of peptic ulcer Hp on positive patients,and to observe ulcer recurrence ,the reinfection rate of Hp,the side effects. Method:84 patients were divided into treatment group and control group on average. The control group used the omeprazole 20 mg,2 times/d;500 mg amoxicillin,4 times/d;Metronidazole 400 mg,4 times/d, all take 1 week. Treatment group omeprazole 20 mg,1/d;500 mg amoxicillin,2 times/d,metronidazole,400 mg,2 times/d,after treatment for 1 week, did’t use any other antiulcer drug. 1 month after the review of gastroscope and Hp,Hp eradicate rate of the patients were observed and ulcer healing rate;After 12 months of follow-up of patients with recurrence rate and infection rates again. Result:Treatment group eradication rate was 95.23%(40/42), the ulcer healing rate was 92.86%(39/42),the control group was 90.48%(38/42),88.09%(37/39),there were no statistical significance(P>0.05);12 months follow-up after treatment group Hp eradication ulcer recurrence in 4.76%(2/42),and Hp infection rate 7.14%(3/42),the control group was 26.19%(11/42),28.57%(12/42),the two groups had statistical significance(P<0.05);Treatment group adverse reaction rate 7.14%(3/42), the control group was 11.90%(5/42),the two groups had no statistical significance(P>0.05). Conclusion:Standard low-dose triple therapy in the treatment of Hp positive peptic ulcer is highly recurrenced ,Hp with highly eradicated,rate of ulcer recurrence and rate of Hp infection is low. It is a valuable program in the clinical application.